temozolomide
CHEBI:CHEBI_72564
Definition
An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical Information
- Molecular Formula
- C6H6N6O2
- Molecular Mass
- 194.15080
- Charge
- 0
- SMILES
- Cn1nnc2c(ncn2c1=O)C(N)=O
- InChI
- InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
- InChIKey
- BPEGJWRSRHCHSN-UHFFFAOYSA-N
Alternative Names
- 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
- 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
- 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
- 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
- 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
- BRN 5547136
- CCRG 81045
- CCRG-81045
- CCRIS 8996
- M & B 39831
- M&B 39831
- MB 39831
- methazolastone
- NSC 362856
- Sch 52365
- Temodal
- Temodar
- temozolomida
- temozolomide
- temozolomidum
- TMZ
Drug Classification
-
monocarboxylic acid amideView Class →
CHEBI:29347
-
triazene derivativeView Class →
CHEBI:72573
-
imidazotetrazineView Class →
CHEBI:72565
-
t279407
-
t279503
-
t280202
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 37776
- oboInOwl#hasDbXref
- Wikipedia:Temozolomide
- core#notation
- CHEBI:72564
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- listing_expiration_date
- 20241231
- route
- INTRAVENOUS
- spl_id
- 0abcfc58-d1ad-af99-e063-6294a90a7847
- package_ndc
- 46014-1460-1
- marketing_start_date
- 20050518
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 37776
- oboInOwl#hasDbXref
- Wikipedia:Temozolomide
- oboInOwl#id
- CHEBI:72564
- generic_name
- Temozolomide
- brand_name
- TEMODAR
- brand_name_base
- TEMODAR
- product_ndc
- 46014-1460
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_22333
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- dosage_form
- INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
- labeler_name
- VALARY LAB PRIVATE LIMITED
- application_number
- NDA022277
- has_treatment
- http://purl.obolibrary.org/obo/DOID_5370
- package_description
- 20 BLISTER PACK in 1 CARTON (47335-890-75) / 1 CAPSULE in 1 BLISTER PACK
- rxcui
- 835948
- active_ingredient_strength
- 2.5 mg/mL
- package_marketing_start_date
- 18-MAY-05
- manufacturer_name
- Zydus Pharmaceuticals USA Inc.
- active_ingredient_name
- TEMOZOLOMIDE
- unii
- YF1K15M17Y
- spl_set_id
- 6a028bd7-9b68-4208-8795-25287e684448
- core#notation
- CHEBI:72564
- pharm_class_moa
- Alkylating Activity [MoA]
- pharm_class
- Alkylating Drug [EPC]
- pharm_class_epc
- Alkylating Drug [EPC]
- nui
- N0000175558
- upc
- 0365162801514
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect33567
- owl#annotatedSource
- t280207
- owl#someValuesFrom
- t980752