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temozolomide

CHEBI:CHEBI_72564

Definition

An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.

Chemical Information

Molecular Formula
C6H6N6O2
Molecular Mass
194.15080
Charge
0
SMILES
Cn1nnc2c(ncn2c1=O)C(N)=O
InChI
InChI=1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChIKey
BPEGJWRSRHCHSN-UHFFFAOYSA-N

Alternative Names

  • 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide
  • 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
  • 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide
  • 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide
  • 8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one
  • BRN 5547136
  • CCRG 81045
  • CCRG-81045
  • CCRIS 8996
  • M & B 39831
  • M&B 39831
  • MB 39831
  • methazolastone
  • NSC 362856
  • Sch 52365
  • Temodal
  • Temodar
  • temozolomida
  • temozolomide
  • temozolomidum
  • TMZ

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:72564
DRON_00010000
37776
oboInOwl#hasDbXref
Wikipedia:Temozolomide

Additional References

Wikipedia:Temozolomide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

package_description
50 kg in 1 DRUM (46014-1460-1)
package_ndc
47335-929-72
listing_expiration_date
20241231
route
INTRAVENOUS
spl_id
0abcfc58-d1ad-af99-e063-6294a90a7847
marketing_start_date
20050518
core#notation
CHEBI:72564
active_ingredient_strength
100 mg/1
pharm_class_moa
Alkylating Activity [MoA]
pharm_class
Alkylating Drug [EPC]
pharm_class_epc
Alkylating Drug [EPC]
nui
N0000175558
upc
0365162801514
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
835948
package_marketing_start_date
18-MAY-05
manufacturer_name
Zydus Pharmaceuticals USA Inc.
active_ingredient_name
TEMOZOLOMIDE
unii
YF1K15M17Y
spl_set_id
6a028bd7-9b68-4208-8795-25287e684448
has_treatment
http://purl.obolibrary.org/obo/DOID_5370
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
labeler_name
VALARY LAB PRIVATE LIMITED
application_number
NDA022277
product_ndc
31722-416
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
37776
oboInOwl#hasDbXref
Wikipedia:Temozolomide
oboInOwl#id
CHEBI:72564
generic_name
Temozolomide
brand_name
TEMODAR
brand_name_base
TEMODAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33567
owl#annotatedSource
t280207
owl#someValuesFrom
t980752