Discuss This Drug

Naloxone

CHEBI:CHEBI_7459

Definition

A synthetic morphinane alkaloid that is morphinone in which the enone double bond has been reduced to a single bond, the hydrogen at position 14 has been replaced by a hydroxy group, and the methyl group attached to the nitrogen has been replaced by an allyl group. A specific opioid antagonist, it is used (commonly as its hydrochloride salt) to reverse the effects of opioids, both following their use of opioids during surgery and in cases of known or suspected opioid overdose.

Chemical Information

Molecular Formula
C19H21NO4
Molecular Mass
327.37430
Charge
0
SMILES
Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
InChI
InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
InChIKey
UZHSEJADLWPNLE-GRGSLBFTSA-N

Alternative Names

  • (-)-naloxone
  • 1-N-Allyl-14-hydroxynordihydromorphinone
  • 17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one
  • 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
  • naloxona
  • naloxone
  • naloxonum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Naloxone
DRON_00010000
7242
core#notation
CHEBI:7459

Additional References

Wikipedia:Naloxone

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
SPRAY, METERED
application_number
NDA208969
product_ndc
71872-7299
package_description
500 g in 1 BOTTLE, GLASS (49452-4836-7)
package_ndc
51662-1620-1
labeler_name
International Medication Systems, Ltd.
marketing_start_date
19861016
rxcui
2680741
manufacturer_name
International Medication Systems, Ltd.
unii
F850569PQR
spl_set_id
7acf3bde-f858-4fbc-8a11-6741a3d27b8e
package_marketing_start_date
14-APR-10
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000036
route
PARENTERAL
spl_id
37a2e84f-b299-423f-b100-5c5556c6dbdf
listing_expiration_date
20241231
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Naloxone
DRON_00010000
7242
oboInOwl#id
CHEBI:7459
generic_name
Naloxone HCL
brand_name
REXTOVY
brand_name_base
REXTOVY
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_90755
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_35649
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_90756
pharm_class
Opioid Antagonists [MoA]
active_ingredient_strength
4 mg/.25mL
active_ingredient_name
NALOXONE
upc
0311917040332
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
core#notation
CHEBI:7459
has_treatment
http://purl.obolibrary.org/obo/DOID_12380
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_82975
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_90756
owl#annotatedSource
t283704
owl#someValuesFrom
t3481770