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travoprost

CHEBI:CHEBI_746859

Definition

The isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol.

Chemical Information

Molecular Formula
C26H35F3O6
Molecular Mass
500.54770
Charge
0
SMILES
CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COc1cccc(c1)C(F)(F)F
InChI
InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
InChIKey
MKPLKVHSHYCHOC-AHTXBMBWSA-N

Alternative Names

  • isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[(alpha,alpha,alpha-trifluoro-m-tolyl)oxy]-1-butenyl}cyclopentyl)-5-heptenoate
  • propan-2-yl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoate
  • Travatan
  • Travatan Z
  • travoprost
  • Travoprost
  • travoprostum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:746859
DRON_00010000
283809
oboInOwl#hasDbXref
Wikipedia:Travoprost

Additional References

Wikipedia:Travoprost

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
labeler_name
GLENMARK PHARMACEUTICALS INC
marketing_start_date
20140131
route
INTRACAMERAL
spl_id
0b6bfa19-339a-46fa-957a-14111c203d56
package_ndc
70069-586-01
application_number
NDA218010
core#notation
CHEBI:746859
brand_name_suffix
Travoprost
pharm_class_epc
Prostaglandin Analog [EPC]
pharm_class
Prostaglandins [CS]
pharm_class_cs
Prostaglandins [CS]
active_ingredient_strength
1 g/g
nui
M0017805
upc
0368462943038
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
283809
oboInOwl#hasDbXref
Wikipedia:Travoprost
oboInOwl#id
CHEBI:746859
brand_name
Travoprost Ophthalmic
brand_name_base
Travoprost Ophthalmic
generic_name
Travoprost Ophthalmic Solution, 0.004%
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
IMPLANT
product_ndc
70069-586
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_66900
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_60782
rxcui
2672093
package_marketing_start_date
16-SEP-13
manufacturer_name
GLENMARK PHARMACEUTICALS INC
active_ingredient_name
TRAVOPROST
package_description
1 BOTTLE in 1 CARTON (70069-586-01) / 2.5 mL in 1 BOTTLE
unii
WJ68R08KX9
spl_set_id
2b64a309-c7c1-4f12-9c1e-99fa8310612c
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33948
owl#annotatedSource
t283683
owl#someValuesFrom
t513425