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Teniposide

CHEBI:CHEBI_75988

Definition

A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.

Chemical Information

Molecular Formula
C32H32O13S
Molecular Mass
656.660
Charge
0
SMILES
[H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=C(C=C3OCOC3=C1)[C@H]2O[C@@H]1O[C@]2([H])CO[C@]([H])(O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1
InChI
InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31+,32-/m0/s1
InChIKey
NRUKOCRGYNPUPR-QBPJDGROSA-N

Alternative Names

  • (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(thiophen-2-ylmethylidene)-beta-D-glucopyranoside
  • 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside)
  • 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside
  • HSDB 6546
  • NSC 122819
  • NSC-122819
  • teniposide
  • teniposido
  • teniposidum
  • VM-26
  • VM26
  • Vumon

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
10362
oboInOwl#hasDbXref
Wikipedia:Teniposide
core#notation
CHEBI:75988

Additional References

Wikipedia:Teniposide

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
10362
oboInOwl#hasDbXref
Wikipedia:Teniposide
oboInOwl#id
CHEBI:75988
core#notation
CHEBI:75988
oboInOwl#hasAlternativeId
CHEBI:9917
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50750
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_50305
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723855
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
owl#annotatedSource
t287037
owl#someValuesFrom
t3088439