Discuss This Drug

trametinib

CHEBI:CHEBI_75998

Definition

A pyridopyrimidine that is used (as its dimethyl sulfoxide addition compound) for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E or V600K mutations, and who have not received prior BRAF inhibitor treatment.

Chemical Information

Molecular Formula
C26H23FIN5O4
Molecular Mass
615.39480
Charge
0
SMILES
CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
InChI
InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChIKey
LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Alternative Names

  • GSK 1120212
  • JTP 74057
  • N-(3-{3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl}phenyl)acetamide
  • trametinib
  • trametinibum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1425099
oboInOwl#hasDbXref
Wikipedia:Trametinib
core#notation
CHEBI:75998

Additional References

Wikipedia:Trametinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1425099
oboInOwl#hasDbXref
Wikipedia:Trametinib
oboInOwl#id
CHEBI:75998
generic_name
Trametinib Acetic Acid
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
POWDER, FOR SOLUTION
labeler_name
GlaxoSmithKline Manufacturing SpA
brand_name
Mekinist
brand_name_base
Mekinist
product_ndc
52482-014
application_number
NDA217513
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_79091
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:75998
rxcui
1425110
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
50 kg/50kg
pharm_class
Protein Kinase Inhibitors [MoA]
marketing_start_date
20130529
package_marketing_start_date
02-SEP-14
manufacturer_name
Novartis Pharmaceuticals Corporation
spl_id
7d7a70c3-36ee-4821-8c79-271128387950
active_ingredient_name
TRAMETINIB
package_ndc
52482-014-00
package_description
.5 kg in 1 DRUM (52482-014-00)
unii
BSB9VJ5TUT
spl_set_id
0002ad27-779d-42ab-83b5-bc65453412a1
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0081260
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112917
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect34485
owl#annotatedSource
t287136
owl#someValuesFrom
t3952135