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dolutegravir

CHEBI:CHEBI_76010

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (4R,12aS)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid with the amino group of 2,4-difluorobenzylamine. Used (as its sodium salt) for treatment of HIV-1.

Chemical Information

Molecular Formula
C20H19F2N3O5
Molecular Mass
419.37880
Charge
0
SMILES
C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
InChI
InChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1
InChIKey
RHWKPHLQXYSBKR-BMIGLBTASA-N

Alternative Names

  • (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
  • S/GSK1349572

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1433868
oboInOwl#hasDbXref
Wikipedia:Dolutegravir
core#notation
CHEBI:76010

Additional References

Wikipedia:Dolutegravir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1433868
oboInOwl#hasDbXref
Wikipedia:Dolutegravir
oboInOwl#id
CHEBI:76010
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
TABLET, FOR SUSPENSION
generic_name
Dolutegravir sodium
product_ndc
53044-001
brand_name
Tivicay
brand_name_base
Tivicay
application_number
NDA204790
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_67268
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_76014
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20130812
labeler_name
RPK Pharmaceuticals, Inc.
spl_id
883c964e-1261-7f3f-e053-2a95a90a60e3
package_ndc
53044-001-01
package_description
19.5 kg in 1 DRUM (53044-001-01)
core#notation
CHEBI:76010
rxcui
1989506
pharm_class
Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor [EPC]
active_ingredient_strength
50 kg/50kg
package_marketing_start_date
12-JUN-20
nui
N0000175656
pharm_class_epc
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]
pharm_class_moa
Nucleoside Reverse Transcriptase Inhibitors [MoA]
active_ingredient_name
DOLUTEGRAVIR SODIUM
unii
1Q1V9V5WYQ
manufacturer_name
RPK Pharmaceuticals, Inc.
spl_set_id
44c4bbcc-fe93-4b4b-ad6a-12f46d2354ec
upc
0349702228139
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect34548
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_76014
owl#annotatedSource
t287125
owl#someValuesFrom
t3865847