riociguat
CHEBI:CHEBI_76018
Definition
A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension
Chemical Information
- Molecular Formula
- C20H19FN8O2
- Molecular Mass
- 422.41570
- Charge
- 0
- SMILES
- COC(=O)N(C)c1c(N)nc(nc1N)-c1nn(Cc2ccccc2F)c2ncccc12
- InChI
- InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
- InChIKey
- WXXSNCNJFUAIDG-UHFFFAOYSA-N
Alternative Names
- Adempas
- BAY 63-2521
- methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate
- Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
- riociguat
- riociguatum
Drug Classification
-
carbamate esterView Class →
CHEBI:23003
-
organofluorine compoundView Class →
CHEBI:37143
-
aminopyrimidineView Class →
CHEBI:38338
-
pyrazolopyridineView Class →
CHEBI:46699
-
t286032
-
t286804
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- oboInOwl#hasDbXref
- Wikipedia:Riociguat
- DRON_00010000
- 1439816
- core#notation
- CHEBI:76018
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- oboInOwl#hasDbXref
- Wikipedia:Riociguat
- DRON_00010000
- 1439816
- brand_name
- Adempas
- brand_name_base
- Adempas
- oboInOwl#id
- CHEBI:76018
- generic_name
- Riociguat
- product_type
- BULK INGREDIENT
- marketing_category
- BULK INGREDIENT
- listing_expiration_date
- 20241231
- route
- ORAL
- dosage_form
- POWDER
- marketing_start_date
- 20170419
- labeler_name
- Bayer HealthCare Pharmaceuticals Inc.
- product_ndc
- 12527-0254
- spl_id
- 2214af48-8b80-4b3c-854a-63c043fb94fa
- package_ndc
- 12527-0254-9
- application_number
- NDA204819
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_76022
- core#notation
- CHEBI:76018
- rxcui
- 1439903
- active_ingredient_strength
- 25 kg/25kg
- package_marketing_start_date
- 19-APR-17
- manufacturer_name
- Bayer HealthCare Pharmaceuticals Inc.
- active_ingredient_name
- RIOCIGUAT
- package_description
- 342857 TABLET, FILM COATED in 1 DRUM (12527-0254-9)
- nui
- N0000190485
- pharm_class_epc
- Soluble Guanylate Cyclase Stimulator [EPC]
- pharm_class
- Guanylate Cyclase Stimulators [MoA]
- pharm_class_moa
- Guanylate Cyclase Stimulators [MoA]
- unii
- RU3FE2Y4XI
- spl_set_id
- 7b57509a-3d5d-41d4-8fed-1471e26372a3
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect34584
- owl#annotatedSource
- t290103
- owl#someValuesFrom
- t2884016