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macitentan

CHEBI:CHEBI_76607

Definition

A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.

Chemical Information

Molecular Formula
C19H20Br2N6O4S
Molecular Mass
588.27300
Charge
0
SMILES
CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1
InChI
InChI=1S/C19H20Br2N6O4S/c1-2-7-26-32(28,29)27-17-16(13-3-5-14(20)6-4-13)18(25-12-24-17)30-8-9-31-19-22-10-15(21)11-23-19/h3-6,10-12,26H,2,7-9H2,1H3,(H,24,25,27)
InChIKey
JGCMEBMXRHSZKX-UHFFFAOYSA-N

Alternative Names

  • ACT 064992
  • ACT-064992
  • ACT064992
  • macitentan
  • macitentanum
  • N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]-N'-propylsulfuric diamide
  • OPSUMIT

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:76607
oboInOwl#hasDbXref
Wikipedia:Macitentan
DRON_00010000
1442132

Additional References

Wikipedia:Macitentan

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:76607
rxcui
2677775
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
50 kg/50kg
pharm_class_epc
Endothelin Receptor Antagonist [EPC]
pharm_class
Endothelin Receptor Antagonists [MoA]
pharm_class_moa
Endothelin Receptor Antagonists [MoA]
active_ingredient_name
MACITENTAN
package_marketing_start_date
09-OCT-17
unii
Z9K9Y9WMVL
nui
N0000175364
marketing_start_date
20240105
spl_id
dbc0d034-6246-49d6-9a52-a476a1338471
package_ndc
82245-0117-1
package_description
20 kg in 1 DRUM (82245-0117-1)
manufacturer_name
Actelion Pharmaceuticals US, Inc.
spl_set_id
6945b183-18d3-40de-afd1-c88e33cc1a63
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Macitentan
DRON_00010000
1442132
oboInOwl#id
CHEBI:76607
generic_name
Macitentan micronized
brand_name
OPSYNVI
brand_name_base
OPSYNVI
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
labeler_name
Actelion Pharmaceuticals US, Inc.
product_ndc
82245-0117
application_number
NDA218490
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_51451
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_76609
owl#annotatedSource
t290440
owl#someValuesFrom
t2916530