ceritinib

CHEBI:CHEBI_78432

Definition

A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.

Chemical Information

Molecular Formula
C28H36ClN5O3S
Molecular Mass
558.137
Charge
0
SMILES
N=1C(=NC(=C(C1)Cl)NC=2C(=CC=CC2)S(C(C)C)(=O)=O)NC=3C=C(C(=CC3OC(C)C)C4CCNCC4)C
InChI
InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
InChIKey
VERWOWGGCGHDQE-UHFFFAOYSA-N

Alternative Names

  • 5-chloro-N(2)-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N(4)-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
  • ceritinib
  • ceritinibum
  • ZYKADIA

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:78432
DRON_00010000
1535457
oboInOwl#hasDbXref
Wikipedia:Ceritinib

Additional References

Wikipedia:Ceritinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:78432
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1535457
oboInOwl#hasDbXref
Wikipedia:Ceritinib
generic_name
Ceritinib
oboInOwl#id
CHEBI:78432
brand_name
ZYKADIA
brand_name_base
ZYKADIA
rxcui
2121061
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
active_ingredient_strength
1 kg/kg
nui
N0000020001
pharm_class_moa
Tyrosine Kinase Inhibitors [MoA]
pharm_class
Tyrosine Kinase Inhibitors [MoA]
pharm_class_epc
Kinase Inhibitor [EPC]
marketing_start_date
20180326
package_marketing_start_date
18-MAR-19
labeler_name
Novartis Pharma Produktions GmbH
manufacturer_name
Novartis Pharmaceuticals Corporation
product_ndc
0078-0694
spl_id
75257e97-1822-452b-851e-b7f4b80f6540
active_ingredient_name
CERITINIB
package_ndc
0078-0694-84
package_description
84 TABLET, FILM COATED in 1 BOTTLE (0078-0694-84)
application_number
NDA211225
unii
K418KG2GET
spl_set_id
fff5d805-4ffd-4e8e-8e63-6f129697563e
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62434
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113088
has_treatment
http://purl.obolibrary.org/obo/DOID_3908
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect35047
owl#annotatedSource
t297202
owl#someValuesFrom
t3408152