ceritinib
CHEBI:CHEBI_78432
Definition
A member of the class of aminopyrimidines that is 2,6-diamino-5-chloropyrimidine in which the amino groups at positions 2 and 6 are respectively carrying 2-methoxy-4-(piperidin-4-yl)-5-methylphenyl and 2-(isopropylsulfonyl)phenyl substituents. Used for the treatment of ALK-positive metastatic non-small cell lung cancer.
Chemical Information
- Molecular Formula
- C28H36ClN5O3S
- Molecular Mass
- 558.137
- Charge
- 0
- SMILES
- N=1C(=NC(=C(C1)Cl)NC=2C(=CC=CC2)S(C(C)C)(=O)=O)NC=3C=C(C(=CC3OC(C)C)C4CCNCC4)C
- InChI
- InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34)
- InChIKey
- VERWOWGGCGHDQE-UHFFFAOYSA-N
Alternative Names
- 5-chloro-N(2)-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N(4)-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
- ceritinib
- ceritinibum
- ZYKADIA
Treatment Applications
-
lung non-squamous non-small cell carcinomaView Disease →
DOID:0080521
-
lung sarcomatoid carcinomaView Disease →
DOID:0080777
-
small cell sarcomaView Disease →
DOID:3098
-
lung squamous cell carcinomaView Disease →
DOID:3907
-
lung leiomyosarcomaView Disease →
DOID:5265
-
laryngeal small cell carcinomaView Disease →
DOID:7144
-
lung superior sulcus carcinomaView Disease →
DOID:8208
Drug Classification
-
sulfoneView Class →
CHEBI:35850
-
organochlorine compoundView Class →
CHEBI:36683
-
piperidinesView Class →
CHEBI:26151
-
aromatic etherView Class →
CHEBI:35618
-
aminopyrimidineView Class →
CHEBI:38338
-
secondary amino compoundView Class →
CHEBI:50995
-
t296179
-
t297245
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1535457
- oboInOwl#hasDbXref
- Wikipedia:Ceritinib
- core#notation
- CHEBI:78432
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1535457
- oboInOwl#hasDbXref
- Wikipedia:Ceritinib
- oboInOwl#id
- CHEBI:78432
- core#notation
- CHEBI:78432
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_62434
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_113088
- has_treatment
- http://purl.obolibrary.org/obo/DOID_3908
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect35047
- owl#annotatedSource
- t297202
- owl#someValuesFrom
- t3408152