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tafamidis

CHEBI:CHEBI_78538

Definition

A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.

Chemical Information

Molecular Formula
C14H7Cl2NO3
Molecular Mass
308.11600
Charge
0
SMILES
OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
InChI
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
InChIKey
TXEIIPDJKFWEEC-UHFFFAOYSA-N

Alternative Names

  • 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
  • 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic acid
  • Fx-1006
  • tafamidis
  • tafamidisum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:78538
DRON_00010000
1545063
oboInOwl#hasDbXref
Wikipedia:Tafamidis

Additional References

Wikipedia:Tafamidis

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
marketing_start_date
20010702
spl_id
31d76cee-bea8-4b70-bb80-70108f7e3645
package_ndc
58159-090-05
package_description
5 kg in 1 DRUM (58159-090-05)
labeler_name
Biophore India Pharmaceuticals Pvt. Ltd
core#notation
CHEBI:78538
rxcui
2168548
active_ingredient_strength
1 kg/1
package_marketing_start_date
04-OCT-05
manufacturer_name
Pfizer Laboratories Div Pfizer Inc
active_ingredient_name
TAFAMIDIS MEGLUMINE
unii
8FG9H9D31J
spl_set_id
1b4121ee-a733-4456-a917-be2603477839
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1545063
oboInOwl#hasDbXref
Wikipedia:Tafamidis
oboInOwl#id
CHEBI:78538
generic_name
Tafamidis (CC)
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
CAPSULE, LIQUID FILLED
brand_name
Vyndaqel
brand_name_base
Vyndaqel
product_ndc
58159-090
application_number
NDA211996
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35470
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_79344
has_treatment
http://purl.obolibrary.org/obo/DOID_11775
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect35051
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_79344
owl#annotatedSource
t300599
owl#someValuesFrom
t2911438
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112335