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apremilast

CHEBI:CHEBI_78540

Definition

A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis.

Chemical Information

Molecular Formula
C22H24N2O7S
Molecular Mass
460.50000
Charge
0
SMILES
CCOc1cc(ccc1OC)[C@@H](CS(C)(=O)=O)N1C(=O)c2cccc(NC(C)=O)c2C1=O
InChI
InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
InChIKey
IMOZEMNVLZVGJZ-QGZVFWFLSA-N

Alternative Names

  • apremilast
  • apremilastum
  • CC 10004
  • CC-10004
  • CC10004
  • N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
  • OTEZLA

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Apremilast
DRON_00010000
1492727
core#notation
CHEBI:78540

Additional References

Wikipedia:Apremilast

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Apremilast
DRON_00010000
1492727
generic_name
Apremilast Form-M
oboInOwl#id
CHEBI:78540
dosage_form
POWDER
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
labeler_name
Amgen Inc
product_ndc
69766-024
brand_name
Otezla
brand_name_base
Otezla
application_number
NDA205437
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68844
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20140325
spl_id
0c36c28f-06e7-02a6-e063-6394a90a5b8b
package_ndc
69766-024-04
package_description
20 kg in 1 DRUM (69766-024-04)
rxcui
2682432
package_marketing_start_date
29-AUG-16
active_ingredient_strength
12 kg/12kg
upc
0355513137607
nui
N0000182960
pharm_class_epc
Phosphodiesterase 4 Inhibitor [EPC]
pharm_class
Phosphodiesterase 4 Inhibitors [MoA]
pharm_class_moa
Phosphodiesterase 4 Inhibitors [MoA]
active_ingredient_name
APREMILAST, (+/-)-
manufacturer_name
Amgen Inc
unii
UP7QBP99PN
spl_set_id
f6b1f516-4972-4d82-bced-113e47b41cc5
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
core#notation
CHEBI:78540
has_treatment
http://purl.obolibrary.org/obo/DOID_0070526
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect35090
owl#annotatedSource
t300685
owl#someValuesFrom
t2992428