Discuss This Drug

ponatinib

CHEBI:CHEBI_78543

Definition

A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I).

Chemical Information

Molecular Formula
C29H27F3N6O
Molecular Mass
532.55950
Charge
0
SMILES
CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
InChI
InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)
InChIKey
PHXJVRSECIGDHY-UHFFFAOYSA-N

Alternative Names

  • 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
  • AP 24534
  • AP-24534
  • AP24534
  • ponatinib
  • ponatinibum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1364347
oboInOwl#hasDbXref
Wikipedia:Ponatinib
core#notation
CHEBI:78543

Additional References

Wikipedia:Ponatinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
1364347
oboInOwl#hasDbXref
Wikipedia:Ponatinib
oboInOwl#id
CHEBI:78543
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
marketing_start_date
20221013
labeler_name
Zhejiang Lepu Pharmaceutical Co., Ltd.
generic_name
ponatinib hydrochloride
product_ndc
48957-0070
brand_name
Iclusig
brand_name_base
Iclusig
application_number
NDA203469
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38637
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CHEBI:78543
rxcui
2473042
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
1 kg/kg
package_marketing_start_date
14-DEC-12
pharm_class
Protein Kinase Inhibitors [MoA]
active_ingredient_name
PONATINIB HYDROCHLORIDE
spl_id
26bc5e7d-30aa-4304-e063-6394a90a6149
package_ndc
48957-0070-1
package_description
25 kg in 1 CONTAINER (48957-0070-1)
manufacturer_name
Takeda Pharmaceuticals America, Inc.
unii
96R6PU3D8J
spl_set_id
16d804b6-4957-43ee-b18c-3b36ec37c5ac
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