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Paromomycin

CHEBI:CHEBI_7934

Definition

An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

Chemical Information

Molecular Formula
C23H45N5O14
Molecular Mass
615.62850
Charge
0
SMILES
NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O
InChI
InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22/h5-23,29-36H,1-4,24-28H2/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey
UOZODPSAJZTQNH-LSWIJEOBSA-N

Alternative Names

  • (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
  • (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside
  • Aminosidin
  • aminosidine
  • Catenulin
  • crestomycin
  • estomycin
  • hydroxymycin
  • Hydroxymycin
  • Monomycin A
  • neomycin E
  • Neomycin E
  • paromomicina
  • paromomycin
  • Paromomycin
  • PAROMOMYCIN
  • Paromomycin I
  • paromomycine
  • paromomycinum
  • paucimycin
  • paucimycinum
  • R 400
  • R-400
  • Zygomycin A1

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
7934
oboInOwl#hasDbXref
Reaxys:72285
core#notation
CHEBI:7934

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
7934
oboInOwl#hasDbXref
Reaxys:72285
oboInOwl#hasAlternativeId
CHEBI:44703
oboInOwl#id
CHEBI:7934
product_type
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
CAPSULE
marketing_start_date
19900814
generic_name
Paromomycin Sulfate
brand_name
Humatin
brand_name_base
Humatin
product_ndc
71052-120
application_number
ANDA065173
labeler_name
DARMERICA, LLC
package_marketing_start_date
23-OCT-18
spl_id
026c7111-b9f3-296d-e063-6294a90afd6f
package_ndc
71052-120-01
package_description
1 kg in 1 PACKAGE (71052-120-01)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35443
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_27955
core#notation
CHEBI:7934
rxcui
207347
active_ingredient_strength
1 kg/kg
active_ingredient_name
PAROMOMYCIN SULFATE
manufacturer_name
Waylis Therapeutics LLC
unii
845NU6GJPS
spl_set_id
a725f022-ec3c-430d-8021-96c861b9893c
upc
0380725250011
pharm_class
Antiprotozoal [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_9065
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect35621
owl#annotatedSource
t300698
owl#someValuesFrom
t938865