Discuss This Drug

Paroxetine

CHEBI:CHEBI_7936

Definition

A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo.

Chemical Information

Molecular Formula
C19H20FNO3
Molecular Mass
329.36540
Charge
0
SMILES
[H][C@]1(CCNC[C@H]1COc1ccc2OCOc2c1)c1ccc(F)cc1
InChI
InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
InChIKey
AHOUBRCZNHFOSL-YOEHRIQHSA-N

Alternative Names

  • (-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
  • (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
  • (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
  • paroxetina
  • Paroxetine
  • paroxetinum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:7936
oboInOwl#hasDbXref
PMID:22263916
DRON_00010000
32937

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect30997
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_64197
owl#someValuesFrom
t2997430
owl#annotatedSource
t300652
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#id
CHEBI:7936
core#notation
CHEBI:7936
oboInOwl#hasDbXref
PMID:22263916
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
DRON_00010000
32937
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50183
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_5115
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723856
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_64197
has_treatment
http://purl.obolibrary.org/obo/DOID_2846