Discuss This Drug

idelalisib

CHEBI:CHEBI_82701

Definition

A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.

Chemical Information

Molecular Formula
C22H18FN7O
Molecular Mass
415.42300
Charge
0
SMILES
CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1
InChI
InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1
InChIKey
IFSDAJWBUCMOAH-HNNXBMFYSA-N

Alternative Names

  • 5-Fluoro-3-phenyl-2-((S)-1-(9H-purin-6-ylamino)-propyl)-3H-quinazolin-4-one
  • 5-fluoro-3-phenyl-2-[(1S)-1-(3H-purin-6-ylamino)propyl]quinazolin-4(3H)-one
  • CAL-101
  • GS-1101
  • ZYDELIG

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:82701
DRON_00010000
1544460
oboInOwl#hasDbXref
Wikipedia:Idelalisib

Additional References

Wikipedia:Idelalisib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:82701
active_ingredient_strength
7 kg/1
nui
N0000175082
pharm_class_moa
Kinase Inhibitors [MoA]
pharm_class
Kinase Inhibitors [MoA]
pharm_class_epc
Kinase Inhibitor [EPC]
active_ingredient_name
IDELALISIB
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_5746
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113592
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36236
owl#annotatedSource
t304165
owl#someValuesFrom
t2999324
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1544460
oboInOwl#hasDbXref
Wikipedia:Idelalisib
oboInOwl#id
CHEBI:82701
generic_name
Idelalisib
rxcui
1544475
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
labeler_name
Natco Pharma Limited
marketing_start_date
20231125
package_marketing_start_date
21-JUN-16
manufacturer_name
Gilead Sciences, Inc.
product_ndc
61958-1702
spl_id
b925df27-bc19-4236-a82c-3194eb9a55f1
package_ndc
61958-1702-1
package_description
60 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (61958-1702-1)
brand_name
Zydelig
brand_name_base
Zydelig
application_number
NDA205858
unii
YG57I8T5M0
spl_set_id
efbdafa9-d18c-4e85-b4a2-1e620fc74e50
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68495
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR