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vorapaxar

CHEBI:CHEBI_82702

Definition

A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethynyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.

Chemical Information

Molecular Formula
C29H33FN2O4
Molecular Mass
492.58170
Charge
0
SMILES
CCOC(=O)N[C@@H]1CC[C@@H]2[C@H](C[C@@H]3[C@@H]([C@@H](C)OC3=O)[C@H]2\C=C\c2ccc(cn2)-c2cccc(F)c2)C1
InChI
InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1
InChIKey
ZBGXUVOIWDMMJE-QHNZEKIYSA-N

Alternative Names

  • ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethenyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
  • vorapaxar

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1537034
oboInOwl#hasDbXref
Wikipedia:Vorapaxar
core#notation
CHEBI:82702

Additional References

Wikipedia:Vorapaxar

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36241
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_83315
owl#annotatedSource
t304040
owl#someValuesFrom
t2884189
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1537034
oboInOwl#hasDbXref
Wikipedia:Vorapaxar
oboInOwl#id
CHEBI:82702
core#notation
CHEBI:82702
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_83313
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_83315
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class