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ent-diltiazem

CHEBI:CHEBI_82813

Definition

A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have R configuration. It is a cGMP-activated K+ channel blocker.

Chemical Information

Molecular Formula
C22H26N2O4S
Molecular Mass
414.51800
Charge
0
SMILES
COc1ccc(cc1)[C@H]1Sc2ccccc2N(CCN(C)C)C(=O)[C@H]1OC(C)=O
InChI
InChI=1S/C22H26N2O4S/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3/h5-12,20-21H,13-14H2,1-4H3/t20-,21+/m0/s1
InChIKey
HSUGRBWQSSZJOP-LEWJYISDSA-N

Alternative Names

  • (-)-cis-diltiazem
  • (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
  • l-cis-diltiazem
  • L-cis-diltiazem

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:82813
oboInOwl#hasDbXref
PMID:9037422

Additional References

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Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#id
CHEBI:82813
core#notation
CHEBI:82813
oboInOwl#hasDbXref
PMID:9037422
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_enantiomer_of
http://purl.obolibrary.org/obo/CHEBI_101278
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50509
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_82816
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_82816
owl#someValuesFrom
t303881
owl#annotatedSource
t304097