naloxegol
CHEBI:CHEBI_82975
Definition
An organic heteropentacyclic compound that is naloxone in which the keto group is replaced by a PEG moiety. Used for treatment of opioid-induced constipation.
Chemical Information
- Molecular Formula
- C34H53NO11
- Molecular Mass
- 651.78470
- Charge
- 0
- SMILES
- COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
- InChI
- InChI=1S/C34H53NO11/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2/h3-5,28-29,32,36-37H,1,6-25H2,2H3/t28-,29+,32-,33-,34+/m0/s1
- InChIKey
- XNKCCCKFOQNXKV-ZRSCBOBOSA-N
Alternative Names
- naloxegol
- NKTR 118
- NKTR-118
- NKTR118
Drug Classification
-
tertiary alcoholView Class →
CHEBI:26878
-
phenolsView Class →
CHEBI:33853
-
aromatic etherView Class →
CHEBI:35618
-
organic heteropentacyclic compoundView Class →
CHEBI:38164
-
polyetherView Class →
CHEBI:46774
-
t302825
-
t303151
-
t303357
-
t304014
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1551777
- oboInOwl#hasDbXref
- Wikipedia:Naloxegol
- core#notation
- CHEBI:82975
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1551777
- oboInOwl#hasDbXref
- Wikipedia:Naloxegol
- oboInOwl#id
- CHEBI:82975
- core#notation
- CHEBI:82975
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#has_parent_hydride
- http://purl.obolibrary.org/obo/CHEBI_35649
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_50137
- chebi#has_functional_parent
- http://purl.obolibrary.org/obo/CHEBI_7459
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect36507
- owl#annotatedSource
- t304120
- owl#someValuesFrom
- t2911294