Discuss This Drug

naloxegol

CHEBI:CHEBI_82975

Definition

An organic heteropentacyclic compound that is naloxone in which the keto group is replaced by a PEG moiety. Used for treatment of opioid-induced constipation.

Chemical Information

Molecular Formula
C34H53NO11
Molecular Mass
651.78470
Charge
0
SMILES
COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC=C)c45
InChI
InChI=1S/C34H53NO11/c1-3-9-35-10-8-33-30-26-4-5-27(36)31(30)46-32(33)28(6-7-34(33,37)29(35)25-26)45-24-23-44-22-21-43-20-19-42-18-17-41-16-15-40-14-13-39-12-11-38-2/h3-5,28-29,32,36-37H,1,6-25H2,2H3/t28-,29+,32-,33-,34+/m0/s1
InChIKey
XNKCCCKFOQNXKV-ZRSCBOBOSA-N

Alternative Names

  • naloxegol
  • NKTR 118
  • NKTR-118
  • NKTR118

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1551777
oboInOwl#hasDbXref
Wikipedia:Naloxegol
core#notation
CHEBI:82975

Additional References

Wikipedia:Naloxegol

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1551777
oboInOwl#hasDbXref
Wikipedia:Naloxegol
oboInOwl#id
CHEBI:82975
core#notation
CHEBI:82975
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_35649
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50137
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_7459
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36507
owl#annotatedSource
t304120
owl#someValuesFrom
t2911294