Discuss This Drug

Proguanil

CHEBI:CHEBI_8455

Definition

A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.

Chemical Information

Molecular Formula
C11H16ClN5
Molecular Mass
253.73100
Charge
0
SMILES
CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1
InChI
InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17)
InChIKey
SSOLNOMRVKKSON-UHFFFAOYSA-N

Alternative Names

  • 1-(p-chlorophenyl)-5-isopropylbiguanide
  • Chlorguanide
  • Chloroguanide
  • N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide
  • N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
  • proguanil
  • proguanilum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Proguanil
DRON_00010000
2382
core#notation
CHEBI:8455

Additional References

Wikipedia:Proguanil

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Proguanil
DRON_00010000
2382
oboInOwl#id
CHEBI:8455
core#notation
CHEBI:8455
listing_expiration_date
20241231
dosage_form
POWDER
marketing_start_date
20000714
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
active_ingredient_strength
1 kg/kg
package_marketing_start_date
14-JUL-00
labeler_name
Viyash Life Sciences Private Limited
generic_name
PROGUANIL HYDROCHLORIDE
product_ndc
82245-0109
spl_id
32bc01ad-903a-4b91-9e05-37ab09229adc
active_ingredient_name
PROGUANIL HYDROCHLORIDE
package_ndc
82245-0109-1
package_description
20 kg in 1 DRUM (82245-0109-1)
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38068
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723855
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http://www.w3.org/2002/07/owl#Class
owl#annotatedSource
t307491
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t1092641