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eltrombopag

CHEBI:CHEBI_85010

Definition

A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).

Chemical Information

Molecular Formula
C25H22N4O4
Molecular Mass
442.46660
Charge
0
SMILES
CC1=NN(C(=O)\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1
InChI
InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-
InChIKey
XDXWLKQMMKQXPV-QYQHSDTDSA-N

Alternative Names

  • 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid
  • 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
711942
oboInOwl#hasDbXref
Wikipedia:Eltrombopag
core#notation
CHEBI:85010

Additional References

Wikipedia:Eltrombopag

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
package_marketing_start_date
22-AUG-16
marketing_start_date
20180927
spl_id
eb46d738-5a67-eb24-e053-2995a90a755f
package_ndc
0480-3273-56
package_description
30 TABLET, FILM COATED in 1 BOTTLE (0480-3273-56)
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
711942
oboInOwl#hasDbXref
Wikipedia:Eltrombopag
oboInOwl#id
CHEBI:85010
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
POWDER, FOR SUSPENSION
labeler_name
SIONC PHARMACEUTICALS PVT LTD
generic_name
Eltrombopag
product_ndc
0480-3273
brand_name
ALVAIZ
brand_name_base
ALVAIZ
application_number
NDA216774
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35703
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:85010
rxcui
2675205
active_ingredient_strength
36 mg/1
manufacturer_name
Novartis Pharmaceuticals Corporation
pharm_class
UGT2B7 Inhibitors [MoA]
active_ingredient_name
ELTROMBOPAG CHOLINE
unii
F9G8XE24IB
spl_set_id
ed51e463-7a03-4858-bbd2-882ce4753d5a
upc
0304803273563
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_1587
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36798
owl#annotatedSource
t310937
owl#someValuesFrom
t2988552