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ledipasvir

CHEBI:CHEBI_85089

Definition

A benzimidazole derivative that is used in combination with sofosbuvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.

Chemical Information

Molecular Formula
C49H54F2N8O6
Molecular Mass
888.99990
Charge
0
SMILES
COC(=O)N[C@@H](C(C)C)C(=O)N1CC2(CC2)C[C@H]1c1nc(c[nH]1)-c1ccc2-c3ccc(cc3C(F)(F)c2c1)-c1ccc2[nH]c(nc2c1)[C@@H]1[C@H]2CC[C@H](C2)N1C(=O)[C@@H](NC(=O)OC)C(C)C
InChI
InChI=1S/C49H54F2N8O6/c1-24(2)39(56-46(62)64-5)44(60)58-23-48(15-16-48)21-38(58)42-52-22-37(55-42)28-9-13-32-31-12-8-26(18-33(31)49(50,51)34(32)19-28)27-10-14-35-36(20-27)54-43(53-35)41-29-7-11-30(17-29)59(41)45(61)40(25(3)4)57-47(63)65-6/h8-10,12-14,18-20,22,24-25,29-30,38-41H,7,11,15-17,21,23H2,1-6H3,(H,52,55)(H,53,54)(H,56,62)(H,57,63)/t29-,30+,38-,39-,40-,41-/m0/s1
InChIKey
VRTWBAAJJOHBQU-KMWAZVGDSA-N

Alternative Names

  • GS 5885
  • GS-5885
  • GS5885
  • WHO 9796
  • methyl [(2S)-1-{(6S)-6-[4-(9,9-difluoro-7-{2-[(1R,3S,4S)-2-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl}-3-methyl-1-oxobutan-2-yl]carbamate

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1591922
oboInOwl#hasDbXref
Wikipedia:Ledipasvir
core#notation
CHEBI:85089

Additional References

Wikipedia:Ledipasvir

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1591922
oboInOwl#hasDbXref
Wikipedia:Ledipasvir
oboInOwl#id
CHEBI:85089
generic_name
ledipasvir and sofosbuvir
rxcui
2204104
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
PELLET
marketing_start_date
20131202
package_marketing_start_date
02-DEC-13
brand_name
Harvoni
brand_name_base
Harvoni
product_ndc
61958-1805
application_number
NDA212477
labeler_name
Gilead Sciences, Inc
manufacturer_name
Gilead Sciences, Inc
spl_id
278effee-f08e-3290-e063-6394a90aed68
package_ndc
61958-1805-1
package_description
90 PELLET in 1 PACKET (61958-1805-1)
unii
WJ6CA3ZU8B
spl_set_id
f4ec77e4-bae8-4db0-b3d5-bde09c5fa075
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_64924
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:85089
pharm_class_moa
RNA Replicase Inhibitors [MoA]
pharm_class
RNA Replicase Inhibitors [MoA]
active_ingredient_strength
33.75 mg/1
nui
N0000191258
active_ingredient_name
SOFOSBUVIR
pharm_class_epc
Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_110874
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36868
owl#annotatedSource
t310893
owl#someValuesFrom
t3454227