Discuss This Drug

netupitant

CHEBI:CHEBI_85155

Definition

A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.

Chemical Information

Molecular Formula
C30H32F6N4O
Molecular Mass
578.59170
Charge
0
SMILES
CN(C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnc(cc1-c1ccccc1C)N1CCN(C)CC1
InChI
InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3
InChIKey
WAXQNWCZJDTGBU-UHFFFAOYSA-N

Alternative Names

  • 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
  • netupitant

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:85155
DRON_00010000
1552337
oboInOwl#hasDbXref
Reaxys:10314678

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:85155
pharm_class_moa
Neurokinin 1 Antagonists [MoA]
pharm_class
Neurokinin 1 Antagonists [MoA]
pharm_class_epc
Substance P/Neurokinin-1 Receptor Antagonist [EPC]
upc
0369639101046
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1552337
oboInOwl#hasDbXref
Reaxys:10314678
oboInOwl#id
CHEBI:85155
rxcui
2374368
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
CAPSULE
active_ingredient_strength
1 kg/kg
nui
N0000175786
marketing_start_date
20141013
unii
7732P08TIR
labeler_name
Helsinn Therapeutics (U.S.), Inc.
package_marketing_start_date
20141013
generic_name
Netupitant
active_ingredient_name
PALONOSETRON
product_ndc
14501-0033
spl_id
0c049cac-82e4-3788-e063-6394a90a1625
package_ndc
14501-0033-2
package_description
50 kg in 1 DRUM (14501-0033-2)
brand_name
AKYNZEO
brand_name_base
AKYNZEO
manufacturer_name
Helsinn Therapeutics (U.S.), Inc.
spl_set_id
8e47618e-af46-4d82-94e8-1507c042252d
application_number
NDA205718
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_55350
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36890
owl#annotatedSource
t310972
owl#someValuesFrom
t3290909