nintedanib

CHEBI:CHEBI_85164

Definition

A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.

Chemical Information

Molecular Formula: C31H33N5O4
Molecular Mass: 539.62480
Charge: 0
SMILES: COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
InChI: InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
InChIKey: XZXHXSATPCNXJR-ZIADKAODSA-N

Alternative Names

BIBF 1120
BIBF-1120
BIBF1120
methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
nintedanib

Treatment Applications

obsolete mesothelial neoplasm
DOID:159

View Disease →
benign fibrous mesothelioma
DOID:2653

View Disease →
obsolete non-mucinous bronchioloalveolar lung carcinoma
DOID:5358

View Disease →
obsolete mixed mucinous and non-mucinous bronchioloalveolar lung carcinoma
DOID:5361

View Disease →
benign intermediate mesothelioma
DOID:5884

View Disease →
asbestos-related lung carcinoma
DOID:7596

View Disease →

Drug Classification

t310407
t310465
t310890
methyl ester
CHEBI:25248

View Class →
N-alkylpiperazine
CHEBI:46845

View Class →
aromatic amide
CHEBI:62733

View Class →
aromatic amine
CHEBI:33860

View Class →
oxindoles
CHEBI:38459

View Class →
aromatic ester
CHEBI:62732

View Class →
enamine
CHEBI:47989

View Class →
t310053
t310228
t310283

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

core#notation: CHEBI:85164
DRON_00010000: 1592737
oboInOwl#hasDbXref: Wikipedia:Nintedanib

Additional References

Wikipedia:Nintedanib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation: CHEBI:85164
oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 1592737
oboInOwl#hasDbXref: Wikipedia:Nintedanib
oboInOwl#id: CHEBI:85164
generic_name: Nintedanib esylate
product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT
dosage_form: CAPSULE
marketing_start_date: 20160923
labeler_name: Hubei Humanwell Chengtian Pharmaceutical Co., Ltd.
brand_name: Ofev
brand_name_base: Ofev
product_ndc: 66499-0062
application_number: NDA205832
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_65207
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of: http://purl.obolibrary.org/obo/CHEBI_85172
rxcui: 1592752
listing_expiration_date: 20241231
route: ORAL
active_ingredient_strength: 100 kg/100kg
pharm_class: Protein Kinase Inhibitors [MoA]
manufacturer_name: Boehringer Ingelheim Pharmaceuticals, Inc.
spl_id: b977c9b3-36ff-1d8a-e053-2995a90abaaa
active_ingredient_name: NINTEDANIB
package_ndc: 66499-0062-1
package_description: 20 kg in 1 DRUM (66499-0062-1)
package_marketing_start_date: 29-JUL-16
unii: 42F62RTZ4G
spl_set_id: da1c9f37-779e-4682-816f-93d0faa4cfc9
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
has_treatment: http://purl.obolibrary.org/obo/DOID_1580
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_112793
rdf-schema#domain: https://w3id.org/def/predibionto#has_side_effect37090
chebi#is_conjugate_acid_of: http://purl.obolibrary.org/obo/CHEBI_85172
owl#annotatedSource: t310996
owl#someValuesFrom: t2914940