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ivabradine

CHEBI:CHEBI_85966

Definition

A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure.

Chemical Information

Molecular Formula
C27H36N2O5
Molecular Mass
468.58510
Charge
0
SMILES
COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC
InChI
InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1
InChIKey
ACRHBAYQBXXRTO-OAQYLSRUSA-N

Alternative Names

  • 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
  • ivabradine
  • S 16257
  • S 16257-2
  • S-16257
  • S-16257-2

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:85966
DRON_00010000
1649480
oboInOwl#hasDbXref
Wikipedia:Ivabradine

Additional References

Wikipedia:Ivabradine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
marketing_start_date
20180729
package_marketing_start_date
21-FEB-14
spl_id
a8984e0f-3f1d-4256-9c55-76a9b89200aa
package_ndc
70771-1863-8
package_description
180 TABLET in 1 BOTTLE (70771-1863-8)
labeler_name
Optimus Drugs Private Limited
core#notation
CHEBI:85966
rxcui
2168596
active_ingredient_strength
2.5 kg/2.5kg
active_ingredient_name
IVABRADINE
manufacturer_name
Zydus Pharmaceuticals USA Inc.
unii
TP19837BZK
spl_set_id
602d1c55-0e4d-452a-a087-888fdbaa7568
upc
0331722053600
pharm_class
Hyperpolarization-activated Cyclic Nucleotide-gated Channel Blocker [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1649480
oboInOwl#hasDbXref
Wikipedia:Ivabradine
oboInOwl#id
CHEBI:85966
generic_name
IIVABRADINE
brand_name
Ivabradine
brand_name_base
Ivabradine
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
SOLUTION
product_ndc
70771-1863
application_number
ANDA213366
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38147
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_85972
has_treatment
http://purl.obolibrary.org/obo/DOID_820
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect37165
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_85972
owl#annotatedSource
t310990
owl#someValuesFrom
t3399457