ivabradine
CHEBI:CHEBI_85966
Definition
A member of the class of benzazepines that is 7,8-dimethoxy-1,3,4,5-tetrahydro-3-benzazepin-2-one in which the amide hydrogen is replaced by a [{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl} group. Used (as its hydrochloride salt) to treat patients with angina who have intolerance to beta blockers and/or heart failure.
Chemical Information
- Molecular Formula
- C27H36N2O5
- Molecular Mass
- 468.58510
- Charge
- 0
- SMILES
- COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC
- InChI
- InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1
- InChIKey
- ACRHBAYQBXXRTO-OAQYLSRUSA-N
Alternative Names
- 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one
- ivabradine
- S 16257
- S 16257-2
- S-16257
- S-16257-2
Drug Classification
-
aromatic etherView Class →
CHEBI:35618
-
tertiary amino compoundView Class →
CHEBI:50996
-
carbobicyclic compoundView Class →
CHEBI:36785
-
benzazepineView Class →
CHEBI:35676
-
t309950
-
t310904
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 1649480
- oboInOwl#hasDbXref
- Wikipedia:Ivabradine
- core#notation
- CHEBI:85966
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 1649480
- oboInOwl#hasDbXref
- Wikipedia:Ivabradine
- oboInOwl#id
- CHEBI:85966
- core#notation
- CHEBI:85966
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_38147
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- chebi#is_conjugate_base_of
- http://purl.obolibrary.org/obo/CHEBI_85972
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- has_treatment
- http://purl.obolibrary.org/obo/DOID_820
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_side_effect37165
- chebi#is_conjugate_acid_of
- http://purl.obolibrary.org/obo/CHEBI_85972
- owl#annotatedSource
- t310990
- owl#someValuesFrom
- t3399457