Discuss This Drug

eluxadoline

CHEBI:CHEBI_85980

Definition

An amino acid amide obtained by the formal condensation of the carboxy group of 4-carbamoyl-2,6-dimethyl-L-phenylalanine with the secondary amino group of 2-methoxy-5-({[(1S)-1-(4-phenylimidazol-2-yl)ethyl]amino}methyl)benzoic acid. It has mixed opioid receptor activity and is used for treatment of irritable bowel syndrome with diarrhoea.

Chemical Information

Molecular Formula
C32H35N5O5
Molecular Mass
569.65080
Charge
0
SMILES
COc1ccc(CN([C@@H](C)c2nc(c[nH]2)-c2ccccc2)C(=O)[C@@H](N)Cc2c(C)cc(cc2C)C(N)=O)cc1C(O)=O
InChI
InChI=1S/C32H35N5O5/c1-18-12-23(29(34)38)13-19(2)24(18)15-26(33)31(39)37(17-21-10-11-28(42-4)25(14-21)32(40)41)20(3)30-35-16-27(36-30)22-8-6-5-7-9-22/h5-14,16,20,26H,15,17,33H2,1-4H3,(H2,34,38)(H,35,36)(H,40,41)/t20-,26-/m0/s1
InChIKey
QFNHIDANIVGXPE-FNZWTVRRSA-N

Alternative Names

  • 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid
  • eluxadoline
  • Viberzi

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:85980
DRON_00010000
1653781
oboInOwl#hasDbXref
Reaxys:12390967

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:85980
active_ingredient_strength
50 kg/50kg
dea_schedule
CIV
active_ingredient_name
ELUXADOLINE
rxcui
1653792
unii
45TPJ4MBQ1
spl_set_id
7821bd40-4c84-4984-951b-6436ae20421a
nui
N0000191866
pharm_class_epc
mu-Opioid Receptor Agonist [EPC]
pharm_class
Opioid mu-Receptor Agonists [MoA]
pharm_class_moa
Opioid mu-Receptor Agonists [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000037
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1653781
oboInOwl#hasDbXref
Reaxys:12390967
oboInOwl#id
CHEBI:85980
brand_name
Viberzi
brand_name_base
Viberzi
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
labeler_name
MSN Life Sciences Private Limited
manufacturer_name
Allergan, Inc.
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
marketing_start_date
20150527
package_marketing_start_date
31-OCT-16
generic_name
Eluxadoline
product_ndc
61874-100
spl_id
0c362d3b-5829-188d-e063-6294a90a02cc
package_ndc
61874-100-60
package_description
60 CARTON in 1 BOTTLE (61874-100-60) / 1 BLISTER PACK in 1 CARTON (61874-100-08) / 8 TABLET, FILM COATED in 1 BLISTER PACK
application_number
NDA206940
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_59282
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_9778
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect37223
owl#annotatedSource
t310911
owl#someValuesFrom
t3006460