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panobinostat

CHEBI:CHEBI_85990

Definition

A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.

Chemical Information

Molecular Formula
C21H23N3O2
Molecular Mass
349.42620
Charge
0
SMILES
Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
InChI
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChIKey
FPOHNWQLNRZRFC-ZHACJKMWSA-N

Alternative Names

  • (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
  • LBH 589
  • LBH589
  • panobinostat

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1603350
oboInOwl#hasDbXref
Wikipedia:Panobinostat
core#notation
CHEBI:85990

Additional References

Wikipedia:Panobinostat

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Additional Attributes

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http://purl.obolibrary.org/obo/DOID_5789
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rdf-schema#domain
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chebi#is_conjugate_acid_of
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chebi_ontology
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1603350
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oboInOwl#id
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core#notation
CHEBI:85990
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61115
oboInOwl#inSubset
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http://www.w3.org/2002/07/owl#Class