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panobinostat

CHEBI:CHEBI_85990

Definition

A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma.

Chemical Information

Molecular Formula
C21H23N3O2
Molecular Mass
349.42620
Charge
0
SMILES
Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
InChI
InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
InChIKey
FPOHNWQLNRZRFC-ZHACJKMWSA-N

Alternative Names

  • (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enamide
  • LBH 589
  • LBH589
  • panobinostat

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1603350
oboInOwl#hasDbXref
Wikipedia:Panobinostat
core#notation
CHEBI:85990

Additional References

Wikipedia:Panobinostat

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
1603350
oboInOwl#hasDbXref
Wikipedia:Panobinostat
oboInOwl#id
CHEBI:85990
core#notation
CHEBI:85990
listing_expiration_date
20241231
dosage_form
POWDER
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
active_ingredient_strength
1 kg/kg
labeler_name
MSN Laboratories Private Limited
marketing_start_date
20180329
package_marketing_start_date
29-MAR-18
generic_name
Panobinostat Lactate
product_ndc
54893-0073
spl_id
0cd8cb40-3f95-e2d8-e063-6294a90a7e9c
active_ingredient_name
PANOBINOSTAT LACTATE
package_ndc
54893-0073-5
package_description
15 kg in 1 DRUM (54893-0073-5)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_61115
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