Discuss This Drug

lenvatinib

CHEBI:CHEBI_85994

Definition

A member of the class of quinolines that is the carboxamide of 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxylic acid. A multi-kinase inhibitor and orphan drug used (as its mesylate salt) for the treatment of various types of thyroid cancer that do not respond to radioiodine.

Chemical Information

Molecular Formula
C21H19ClN4O4
Molecular Mass
426.854
Charge
0
SMILES
C=1(C(=CC2=C(C1)N=CC=C2OC3=CC(=C(C=C3)NC(NC4CC4)=O)Cl)C(N)=O)OC
InChI
InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)
InChIKey
WOSKHXYHFSIKNG-UHFFFAOYSA-N

Alternative Names

  • 4-(3-Chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide
  • 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide
  • E 7080
  • E7080
  • lenvatinib
  • UNII-EE083865G2

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:85994
DRON_00010000
1603296
oboInOwl#hasDbXref
Wikipedia:Lenvatinib

Additional References

Wikipedia:Lenvatinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:85994
rxcui
2054159
route
ORAL
active_ingredient_strength
1 kg/kg
nui
N0000020000
pharm_class_epc
Kinase Inhibitor [EPC]
pharm_class
Receptor Tyrosine Kinase Inhibitors [MoA]
package_marketing_start_date
05-OCT-21
manufacturer_name
Eisai Inc.
active_ingredient_name
LENVATINIB MESYLATE
package_ndc
11071-913-01
package_description
42000 CAPSULE in 1 DRUM (11071-913-01)
unii
EE083865G2
spl_set_id
f4bedd21-efde-44c6-9d9c-b48b78d7ed1e
pharm_class_moa
Receptor Tyrosine Kinase Inhibitors [MoA]
spl_id
df47080a-cde9-c875-e053-2a95a90a580e
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1603296
oboInOwl#hasDbXref
Wikipedia:Lenvatinib
oboInOwl#id
CHEBI:85994
generic_name
Lenvatinib Mesylate MIBK
dosage_form
CAPSULE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
marketing_start_date
20180626
labeler_name
Eisai Inc.
brand_name
Lenvima
brand_name_base
Lenvima
product_ndc
11071-913
application_number
NDA206947
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_65207
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_85998
has_treatment
http://purl.obolibrary.org/obo/DOID_0081457
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect37264
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_85998
owl#annotatedSource
t310961
owl#someValuesFrom
t2911554