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Pyrimethamine

CHEBI:CHEBI_8673

Definition

An aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

Chemical Information

Molecular Formula
C12H13ClN4
Molecular Mass
248.71100
Charge
0
SMILES
CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1
InChI
InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
InChIKey
WKSAUQYGYAYLPV-UHFFFAOYSA-N

Alternative Names

  • 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine
  • 2,4-Diamino-5-(p-chlorophenyl)-6-ethylpyrimidine
  • 2,4-Diamino-5-chlorophenyl-6-ethylpyrimidine
  • 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine
  • 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine
  • 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine
  • 5-(4'-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine
  • CD
  • Chloridine
  • Chloridyn
  • Diaminopyritamin
  • Ethylpyrimidine
  • pirimetamina
  • Primethamine
  • pyrimethamine
  • pyrimethaminum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Pyrimethamine
DRON_00010000
9010
core#notation
CHEBI:8673

Additional References

Wikipedia:Pyrimethamine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
route
ORAL
marketing_start_date
20191224
spl_id
1dedf70a-b9d1-12b5-e063-6394a90ae2c4
package_ndc
71052-215-05
package_description
5000 g in 1 CONTAINER (71052-215-05)
labeler_name
Alvogen Inc.
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Pyrimethamine
DRON_00010000
9010
oboInOwl#id
CHEBI:8673
generic_name
PYRIMETHAMINE
brand_name
Daraprim
brand_name_base
Daraprim
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
product_ndc
71052-215
application_number
ANDA216983
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_38068
core#notation
CHEBI:8673
rxcui
201912
nui
N0000175934
pharm_class_moa
Dihydrofolate Reductase Inhibitors [MoA]
pharm_class
Dihydrofolate Reductase Inhibitor Antimalarial [EPC]
active_ingredient_strength
5000 g/5000g
package_marketing_start_date
22-AUG-13
manufacturer_name
OAKRUM PHARMA, LLC
active_ingredient_name
PYRIMETHAMINE
unii
Z3614QOX8W
spl_set_id
8ed8141b-e6c0-4a6b-8a08-2858c8c8bd4a
upc
0372647330032
pharm_class_epc
Dihydrofolate Reductase Inhibitor Antimalarial [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_13342
owl#annotatedSource
t314425
owl#someValuesFrom
t936242