Discuss This Drug

quinapril

CHEBI:CHEBI_8713

Definition

A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.

Chemical Information

Molecular Formula
C25H30N2O5
Molecular Mass
438.517
Charge
0
SMILES
C1C2=C(C[C@H](N1C([C@@H](N[C@H](C(OCC)=O)CCC=3C=CC=CC3)C)=O)C(O)=O)C=CC=C2
InChI
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1
InChIKey
JSDRRTOADPPCHY-HSQYWUDLSA-N

Alternative Names

  • (3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • (3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  • quinapril
  • Quinapril
  • quinaprilum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
35208
oboInOwl#hasDbXref
Wikipedia:Quinapril
core#notation
CHEBI:8713

Additional References

Wikipedia:Quinapril

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
labeler_name
Rolabo Outsourcing S.L.
marketing_start_date
20160316
spl_id
56bcc2d8-ba10-4719-b97d-9c8244376af6
package_ndc
0071-5212-23
application_number
NDA020125
product_ndc
68001-189
package_description
90 TABLET, FILM COATED in 1 BOTTLE (0071-5212-23)
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
35208
oboInOwl#hasDbXref
Wikipedia:Quinapril
oboInOwl#id
CHEBI:8713
generic_name
Quinapril and Hydrochlorothiazide
brand_name
Quinapril and Hydrochlorothiazide
brand_name_base
Quinapril and Hydrochlorothiazide
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723853
rxcui
882559
manufacturer_name
Cipla USA Inc.
package_marketing_start_date
29-APR-13
core#notation
CHEBI:8713
active_ingredient_name
QUINAPRIL HYDROCHLORIDE
active_ingredient_strength
50 kg/50kg
unii
33067B3N2M
nui
M0471776
pharm_class_epc
Thiazide Diuretic [EPC]
pharm_class
Angiotensin-converting Enzyme Inhibitors [MoA]
pharm_class_pe
Increased Diuresis [PE]
pharm_class_cs
Thiazides [CS]
spl_set_id
fb069caa-14d0-4f76-b662-6145fb4cc276
upc
0362135668907
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect37516
owl#annotatedSource
t314374
owl#someValuesFrom
t979218