Discuss This Drug

rofecoxib

CHEBI:CHEBI_8887

Definition

A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.

Chemical Information

Molecular Formula
C17H14O4S
Molecular Mass
314.35600
Charge
0
SMILES
CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1
InChI
InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
InChIKey
RZJQGNCSTQAWON-UHFFFAOYSA-N

Alternative Names

  • 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone
  • 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
  • 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
  • Ceoxx
  • rofecoxib
  • Rofecoxib
  • rofecoxibum
  • Vioxx

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Rofecoxib
DRON_00010000
232158
core#notation
CHEBI:8887

Additional References

Wikipedia:Rofecoxib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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CHEBI:8887
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RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50629
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