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SN-38

CHEBI:CHEBI_8988

Definition

A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.

Chemical Information

Molecular Formula
C22H20N2O5
Molecular Mass
392.411
Charge
0
SMILES
CCC1=C2C=C(O)C=CC2=NC2=C1CN1C2=CC2=C(COC(=O)[C@]2(O)CC)C1=O
InChI
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3/t22-/m0/s1
InChIKey
FJHBVJOVLFPMQE-QFIPXVFZSA-N

Alternative Names

  • (4S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 10-Hydroxy-7-ethylcamptothecin
  • 7-Ethyl-10-hydroxy-20(S)-camptothecin
  • 7-Ethyl-10-hydroxycamptothecin
  • NK 012
  • NK-012
  • SN 38
  • SN 38 lactone
  • SN-38

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:SN-38
core#notation
CHEBI:8988

Additional References

Wikipedia:SN-38

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_80630
owl#someValuesFrom
t300239
owl#annotatedSource
t317885
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:SN-38
oboInOwl#id
CHEBI:8988
core#notation
CHEBI:8988
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50276
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class