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quizartinib

CHEBI:CHEBI_90217

Definition

A member of the class of phenylureas that is urea in which one of the amino groups has been substituted by a 5-tert-butyl-1,2-oxazol-3-yl group while the other has been substituted by a phenyl group substituted at the para- position by an imidazo[2,1-b][1,3]benzothiazol-2-yl group that, in turn, is substituted at position 7 by a 2-(morpholin-4-yl)ethoxy group.

Chemical Information

Molecular Formula
C29H32N6O4S
Molecular Mass
560.669
Charge
0
SMILES
S1C2=C(N3C1=NC(=C3)C4=CC=C(NC(=O)NC5=NOC(C(C)(C)C)=C5)C=C4)C=CC(OCCN6CCOCC6)=C2
InChI
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChIKey
CVWXJKQAOSCOAB-UHFFFAOYSA-N

Alternative Names

  • 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea
  • AC 010220
  • AC 220
  • AC010220
  • AC220
  • N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)urea
  • quizartinib
  • quizartinibum
  • Vanflyta

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2643048
oboInOwl#hasDbXref
Wikipedia:Quizartinib
core#notation
CHEBI:90217

Additional References

Wikipedia:Quizartinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2643048
oboInOwl#hasDbXref
Wikipedia:Quizartinib
oboInOwl#id
CHEBI:90217
rxcui
2643064
product_type
DRUG FOR FURTHER PROCESSING
marketing_category
DRUG FOR FURTHER PROCESSING
listing_expiration_date
20251231
route
ORAL
dosage_form
TABLET, FILM COATED
marketing_start_date
20230127
package_marketing_start_date
27-JAN-23
labeler_name
Daiichi Sankyo Inc.
generic_name
QUIZARTINIB DIHYDROCHLORIDE
brand_name
VANFLYTA
brand_name_base
VANFLYTA
product_ndc
47049-031
application_number
NDA216993
manufacturer_name
Daiichi Sankyo Inc.
spl_id
e75365b3-15bf-440f-b429-31abc6ec9caa
package_ndc
47049-031-00
package_description
40486 TABLET, FILM COATED in 1 DRUM (47049-031-00)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_167704
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:90217
pharm_class
FMS-like Receptor Tyrosine Kinase 3 (FLT3) Inhibitors [MoA]
active_ingredient_name
QUIZARTINIB DIHYDROCHLORIDE
active_ingredient_strength
17.7 mg/1
unii
WK7Q6ZIZ10
spl_set_id
29cdbcfe-497d-4e78-bb7b-2d4acafe8e86
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0081086
owl#annotatedSource
t317818
owl#someValuesFrom
t4009855