Discuss This Drug

Cobimetinib

CHEBI:CHEBI_90851

Definition

A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.

Chemical Information

Molecular Formula
C21H21F3IN3O2
Molecular Mass
531.311
Charge
0
SMILES
C1=C(C(=C(C(=C1)C(N2CC(C2)(O)[C@H]3NCCCC3)=O)NC4=CC=C(C=C4F)I)F)F
InChI
InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
InChIKey
BSMCAPRUBJMWDF-KRWDZBQOSA-N

Alternative Names

  • [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
  • cobimetinib
  • GDC 0973
  • GDC-0973
  • GDC0973
  • RG 7420
  • RG7420
  • Xl 518
  • Xl-518
  • XL518

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1722365
oboInOwl#hasDbXref
Wikipedia:Cobimetinib
core#notation
CHEBI:90851

Additional References

Wikipedia:Cobimetinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_3846
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_90854
owl#annotatedSource
t317865
owl#someValuesFrom
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chebi_ontology
DRON_00010000
1722365
oboInOwl#hasDbXref
Wikipedia:Cobimetinib
oboInOwl#id
CHEBI:90851
core#notation
CHEBI:90851
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_79091
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_90854
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class