Discuss This Drug

Cobimetinib

CHEBI:CHEBI_90851

Definition

A member of the class of N-acylazetidines obtained by selective formal condensation of the carboxy group of 3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzoic acid with the secondary amino group from the azetidine ring of 3-[(2S)-piperidin-2-yl]azetidin-3-ol. An inhibitor of mitogen-activated protein kinase that is used (as its fumarate salt) in combination with vemurafenib for the treatment of patients with unresectable or metastatic melanoma.

Chemical Information

Molecular Formula
C21H21F3IN3O2
Molecular Mass
531.311
Charge
0
SMILES
C1=C(C(=C(C(=C1)C(N2CC(C2)(O)[C@H]3NCCCC3)=O)NC4=CC=C(C=C4F)I)F)F
InChI
InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
InChIKey
BSMCAPRUBJMWDF-KRWDZBQOSA-N

Alternative Names

  • [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]{3-hydroxy-3-[(2S)-piperidin-2-yl]azetidin-1-yl}methanone
  • cobimetinib
  • GDC 0973
  • GDC-0973
  • GDC0973
  • RG 7420
  • RG7420
  • Xl 518
  • Xl-518
  • XL518

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1722365
oboInOwl#hasDbXref
Wikipedia:Cobimetinib
core#notation
CHEBI:90851

Additional References

Wikipedia:Cobimetinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1722365
oboInOwl#hasDbXref
Wikipedia:Cobimetinib
oboInOwl#id
CHEBI:90851
core#notation
CHEBI:90851
rxcui
1722376
product_type
HUMAN PRESCRIPTION DRUG
marketing_category
NDA
listing_expiration_date
20251231
route
ORAL
dosage_form
TABLET, FILM COATED
active_ingredient_strength
20 mg/1
pharm_class
Kinase Inhibitors [MoA]
marketing_start_date
20151110
package_marketing_start_date
20151110
labeler_name
Genentech, Inc.
manufacturer_name
Genentech, Inc.
generic_name
COBIMETINIB
brand_name
Cotellic
brand_name_base
Cotellic
product_ndc
50242-717
application_number
NDA206192
spl_id
874ddd8b-49a8-4f47-90f0-3542fd0ba9bb
active_ingredient_name
COBIMETINIB FUMARATE
package_ndc
50242-717-86
package_description
63 TABLET, FILM COATED in 1 BOTTLE, PLASTIC (50242-717-86)
unii
6EXI96H8SV
spl_set_id
c387579e-cee0-4334-bd1e-73f93ac1bde6
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_79091
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_90854
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_3846
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_90854
owl#annotatedSource
t317865
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t2909564