Discuss This Drug

rolapitant

CHEBI:CHEBI_90908

Definition

An azaspiro compound that is 1,7-diazaspiro[4.5]decan-2-one carrying additional phenyl and 1-{[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl substituents at position 8. Used (in the form of the hydrochloride hydrate) for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

Chemical Information

Molecular Formula
C25H26F6N2O2
Molecular Mass
500.477
Charge
0
SMILES
C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)[C@H](OC[C@@]2(NC[C@]3(CC2)CCC(N3)=O)C4=CC=CC=C4)C
InChI
InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1
InChIKey
FIVSJYGQAIEMOC-ZGNKEGEESA-N

Alternative Names

  • (5S,8S)-8-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
  • rolapitant
  • SCH 619734
  • SCH-619734

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:90908
DRON_00010000
1665496
oboInOwl#hasDbXref
Reaxys:15570068

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:90908
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1665496
oboInOwl#hasDbXref
Reaxys:15570068
oboInOwl#id
CHEBI:90908
generic_name
Rolapitant
rxcui
1673373
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
POWDER
pharm_class
Neurokinin 1 Antagonists [MoA]
active_ingredient_strength
100 kg/100kg
labeler_name
TerSera Therapeutics LLC
product_ndc
70720-101
marketing_start_date
20160725
spl_id
5de36f8a-cbc2-4884-8fcf-e9302d41c2f8
active_ingredient_name
ROLAPITANT
package_ndc
70720-101-02
package_description
2 TABLET in 1 BLISTER PACK (70720-101-02)
package_marketing_start_date
20190806
manufacturer_name
TerSera Therapeutics LLC
brand_name
Varubi
brand_name_base
Varubi
application_number
NDA206500
unii
57O5S1QSAQ
spl_set_id
a52896cd-4a98-49b8-82db-bf1985a64d97
upc
0370720101029
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_55350
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_90913
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect38082
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_90913
owl#annotatedSource
t317804
owl#someValuesFrom
t3291315