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ixazomib

CHEBI:CHEBI_90942

Definition

A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.

Chemical Information

Molecular Formula
C14H19BCl2N2O4
Molecular Mass
361.029
Charge
0
SMILES
C(NCC(=O)N[C@@H](CC(C)C)B(O)O)(C1=CC(=CC=C1Cl)Cl)=O
InChI
InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
InChIKey
MXAYKZJJDUDWDS-LBPRGKRZSA-N

Alternative Names

  • ixazomib
  • MLN 2238
  • MLN-2238
  • MLN2238
  • N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:90942
DRON_00010000
1723735
oboInOwl#hasDbXref
Wikipedia:Ixazomib

Additional References

Wikipedia:Ixazomib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:90942
rxcui
1723772
active_ingredient_strength
2.3 mg/1
pharm_class
Proteasome Inhibitors [MoA]
manufacturer_name
Takeda Pharmaceuticals America, Inc.
package_marketing_start_date
20151120
active_ingredient_name
IXAZOMIB CITRATE
unii
46CWK97Z3K
spl_set_id
038f2461-834b-4488-9ebd-863c83eef5a7
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0080937
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect38162
owl#annotatedSource
t317873
owl#someValuesFrom
t3003340
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1723735
oboInOwl#hasDbXref
Wikipedia:Ixazomib
oboInOwl#id
CHEBI:90942
generic_name
Ixazomib Citrate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
CAPSULE
marketing_start_date
20151212
labeler_name
Chunghwa Chemical Synthesis & Biotech. Ltd
product_ndc
48957-0056
spl_id
c186dc29-b3b6-795e-e053-2a95a90a4bdc
package_ndc
48957-0056-1
package_description
.5 kg in 1 BOTTLE, PLASTIC (48957-0056-1)
brand_name
NINLARO
brand_name_base
NINLARO
application_number
NDA208462
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_49103
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR