Discuss This Drug

osimertinib

CHEBI:CHEBI_90943

Definition

A member of the class of aminopyrimidines that is 4-(1-methylindol-3-yl)pyrimidin-2-amine in which one of the amino hydrogens is replaced by a 2-methoxy-4-[2-(dimethylamino)ethyl](methyl)amino-5-acrylamidophenyl group. Used (as the mesylate salt) for treatment of EGFR T790M mutation positive non-small cell lung cancer.

Chemical Information

Molecular Formula
C28H33N7O2
Molecular Mass
499.608
Charge
0
SMILES
CN1C=2C(C(C3=NC(NC4=C(OC)C=C(C(=C4)NC(C=C)=O)N(CCN(C)C)C)=NC=C3)=C1)=CC=CC2
InChI
InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)
InChIKey
DUYJMQONPNNFPI-UHFFFAOYSA-N

Alternative Names

  • AZD 9291
  • AZD-9291
  • AZD9291
  • mereletinib
  • N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)acrylamide
  • N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
  • osimertinib
  • osimertinibum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:90943
DRON_00010000
1721560
oboInOwl#hasDbXref
Wikipedia:Osimertinib

Additional References

Wikipedia:Osimertinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_4832
core#notation
CHEBI:90943
rxcui
1721583
listing_expiration_date
20241231
route
ORAL
nui
N0000175082
pharm_class_moa
Kinase Inhibitors [MoA]
pharm_class
Kinase Inhibitors [MoA]
active_ingredient_strength
1 kg/kg
marketing_start_date
20151113
pharm_class_epc
Kinase Inhibitor [EPC]
package_marketing_start_date
29-DEC-17
manufacturer_name
AstraZeneca Pharmaceuticals LP
spl_id
ff12dbd0-2f28-4f19-bc69-d2860cd5894d
active_ingredient_name
OSIMERTINIB MESYLATE
package_ndc
0310-1350-95
package_description
1 BLISTER PACK in 1 CARTON (0310-1350-95) / 10 TABLET, FILM COATED in 1 BLISTER PACK
labeler_name
AstraZeneca Pharmaceuticals LP
unii
3C06JJ0Z2O
spl_set_id
5e81b4a7-b971-45e1-9c31-29cea8c87ce7
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1721560
oboInOwl#hasDbXref
Wikipedia:Osimertinib
oboInOwl#id
CHEBI:90943
generic_name
Osimertinib Mesylate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
POWDER
product_ndc
0310-1350
brand_name
TAGRISSO
brand_name_base
TAGRISSO
application_number
NDA208065
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_74440
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_90949
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112782
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect38191
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_90949
owl#annotatedSource
t317899
owl#someValuesFrom
t2993151