Discuss This Drug

lumacaftor

CHEBI:CHEBI_90951

Definition

An aromatic amide obtained by formal condensation of the carboxy group of 1-(2,2-difluoro-1,3-benzodioxol-5-yl)cyclopropane-1-carboxylic acid with the aromatic amino group of 3-(6-amino-3-methylpyridin-2-yl)benzoic acid. Used for the treatment of cystic fibrosis.

Chemical Information

Molecular Formula
C24H18F2N2O5
Molecular Mass
452.408
Charge
0
SMILES
C1(C(NC2=CC=C(C(=N2)C3=CC(=CC=C3)C(O)=O)C)=O)(C4=CC5=C(C=C4)OC(O5)(F)F)CC1
InChI
InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
InChIKey
UFSKUSARDNFIRC-UHFFFAOYSA-N

Alternative Names

  • 3-(6-{[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carbonyl]amino}-3-methylpyridin-2-yl)benzoic acid
  • lumacaftor
  • VRT 826809
  • VRT-826809
  • VX 809
  • VX-809

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:90951
DRON_00010000
1655922
oboInOwl#hasDbXref
Wikipedia:Lumacaftor

Additional References

Wikipedia:Lumacaftor

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:90951
active_ingredient_strength
94 mg/1
pharm_class_moa
P-Glycoprotein Inducers [MoA]
pharm_class
P-Glycoprotein Inducers [MoA]
nui
N0000191264
active_ingredient_name
LUMACAFTOR
rxcui
2053512
unii
EGP8L81APK
spl_set_id
3fc1c40e-cfac-47a1-9e1a-61ead3570600
pharm_class_epc
Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect38197
owl#annotatedSource
t317881
owl#someValuesFrom
t3309075
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1655922
oboInOwl#hasDbXref
Wikipedia:Lumacaftor
oboInOwl#id
CHEBI:90951
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
GRANULE
marketing_start_date
20190611
package_marketing_start_date
11-JUN-19
labeler_name
Vertex Pharmaceuticals Incorporated
manufacturer_name
Vertex Pharmaceuticals Incorporated
generic_name
Lumacaftor and Ivacaftor
brand_name
ORKAMBI
brand_name_base
ORKAMBI
product_ndc
43798-004
application_number
NDA206038
spl_id
1210e305-295f-f94d-e063-6394a90a532c
package_ndc
43798-004-01
package_description
1 POUCH in 1 DRUM (43798-004-01) / 1 BAG in 1 POUCH / 17700 TABLET, FILM COATED in 1 BAG
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_71031
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR