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Sugammadex

CHEBI:CHEBI_90953

Definition

An octasaccharide derivative that is gamma-cyclodextrin in which all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. Used (as the octasodium salt) for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.

Chemical Information

Molecular Formula
C72H112O48S8
Molecular Mass
2002.162
Charge
0
SMILES
O1[C@H](CSCCC(=O)O)[C@@H]2[C@H](O)[C@@H](O)[C@H]1O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@@H]([C@@H]([C@H]9O)O)O2)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(=O)O)CSCCC(O)=O)CSCCC(=O)O
InChI
InChI=1S/C72H112O48S8/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m1/s1
InChIKey
WHRODDIHRRDWEW-VTHZAVIASA-N

Alternative Names

  • sugammadex

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1726988
oboInOwl#hasDbXref
Wikipedia:Sugammadex
core#notation
CHEBI:90953

Additional References

Wikipedia:Sugammadex

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

listing_expiration_date
20241231
marketing_start_date
20210130
route
INTRAVENOUS
labeler_name
Merck Sharp & Dohme LLC
spl_id
d574487b-2512-1562-e053-2a95a90a3e2a
package_ndc
62227-016-01
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1726988
oboInOwl#hasDbXref
Wikipedia:Sugammadex
oboInOwl#id
CHEBI:90953
generic_name
SUGAMMADEX
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, SOLUTION
product_ndc
62227-016
brand_name
BRIDION
brand_name_base
BRIDION
application_number
NDA022225
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_51372
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_495056
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_90957
core#notation
CHEBI:90953
rxcui
1727001
active_ingredient_strength
200 mg/2mL
package_marketing_start_date
25-FEB-20
manufacturer_name
Merck Sharp & Dohme LLC
active_ingredient_name
SUGAMMADEX
package_description
30 kg in 1 BAG (62227-016-01)
unii
ERJ6X2MXV7
spl_set_id
9e3eb206-5c35-2c93-e053-2a95a90a9df0
pharm_class
gamma-Cyclodextrins [CS]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0040034
Name
http://purl.obolibrary.org/obo/DOID_0040034
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_90957
owl#annotatedSource
t317892
owl#someValuesFrom
t3009401