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tiotropium

CHEBI:CHEBI_90960

Definition

A quaternary ammonium ion obtained by methylation of the tertiary amino group of (1alpha,2beta,4beta,5alpha,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane. Used (in the form of the bromide hydrate) for maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.

Chemical Information

Molecular Formula
C19H22NO4S2
Molecular Mass
392.515
Charge
+1
SMILES
O([C@H]1C[C@]2([C@@H]3O[C@@H]3[C@](C1)([H])[N+]2(C)C)[H])C(C(C4=CC=CS4)(C=5SC=CC5)O)=O
InChI
InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11-,12-,13+,16-,17+
InChIKey
LERNTVKEWCAPOY-DZZGSBJMSA-N

Alternative Names

  • (1alpha,2beta,4beta,5alpha,7beta)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0(2,4)]nonane
  • 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane
  • BA 679 BR
  • BA-679 BR

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
69120
oboInOwl#hasDbXref
Reaxys:9806715
core#notation
CHEBI:90960

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

rxcui
2166204
route
RESPIRATORY (INHALATION)
package_marketing_start_date
30-JAN-04
active_ingredient_strength
1.562 ug/1
manufacturer_name
Boehringer Ingelheim Pharmaceuticals Inc.
active_ingredient_name
TIOTROPIUM BROMIDE MONOMETHANOLATE
package_ndc
0597-0075-75
package_description
1 BLISTER PACK in 1 CARTON (0597-0075-75) / 5 CAPSULE in 1 BLISTER PACK
unii
XX112XZP0J
spl_set_id
820839ef-e53d-47e8-a3b9-d911ff92e6a9
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
69120
oboInOwl#hasDbXref
Reaxys:9806715
oboInOwl#id
CHEBI:90960
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
SPRAY, METERED
marketing_start_date
20110704
labeler_name
Boehringer Ingelheim Pharmaceuticals Inc.
generic_name
Tiotropium Bromide Monomethanolate
brand_name
Spiriva Respimat
brand_name_base
Spiriva Respimat
product_ndc
0597-0075
application_number
NDA021936
spl_id
74c01ed6-9299-467e-bda9-8043c8d887fb
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_48876
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:90960
pharm_class
Cholinergic Antagonists [MoA]
brand_name_suffix
HandiHaler
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2841
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect38227
owl#annotatedSource
t317576
owl#someValuesFrom
t3499788