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momelotinib

CHEBI:CHEBI_91407

Definition

A benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis.

Chemical Information

Molecular Formula
C23H22N6O2
Molecular Mass
414.469
Charge
0
SMILES
O=C(NCC#N)C1=CC=C(C=C1)C2=CC=NC(NC3=CC=C(C=C3)N4CCOCC4)=N2
InChI
InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
InChIKey
ZVHNDZWQTBEVRY-UHFFFAOYSA-N

Alternative Names

  • CYT 11387
  • CYT 387
  • CYT-11387
  • CYT-387
  • CYT387
  • GS-0387
  • LM-1149
  • momelotinib
  • momelotinibum
  • N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide
  • N-(cyanomethyl)-4-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)benzamide
  • N-(cyanomethyl)-4-(2-((4-morpholinophenyl)-amino)pyrimidin-4-yl)benzamide
  • N-(cyanomethyl)-4-[2-[4-(4-morpholinyl)anilino]-4-pyrimidinyl]benzamide
  • N-(cyanomethyl)-4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzamide
  • Ojjaara

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:91407
DRON_00010000
2665204
oboInOwl#hasDbXref
Wikipedia:Momelotinib

Additional References

Wikipedia:Momelotinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:91407
rxcui
2665224
active_ingredient_strength
1 kg/kg
package_marketing_start_date
08-FEB-23
pharm_class
Kinase Inhibitors [MoA]
manufacturer_name
GlaxoSmithKline LLC
active_ingredient_name
MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATE
package_description
30 TABLET in 1 BOTTLE (81864-103-30)
unii
LDX8893L5D
spl_set_id
4a672fd1-eb7b-4aa9-9b23-845e4b5dc400
upc
0381864101301
package_ndc
81864-101-30
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2665204
oboInOwl#hasDbXref
Wikipedia:Momelotinib
oboInOwl#id
CHEBI:91407
brand_name
Ojjaara
brand_name_base
Ojjaara
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
route
ORAL
dosage_form
POWDER
marketing_start_date
20230208
labeler_name
GlaxoSmithKline LLC
generic_name
Momelotinib dihydrochloride monohydrate
product_ndc
81864-103
application_number
NDA216873
spl_id
f42ac08e-fd48-2c15-e053-2995a90af7e6
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76617
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_3347
owl#annotatedSource
t321323
owl#someValuesFrom
t4001321