Discuss This Drug

Simvastatin

CHEBI:CHEBI_9150

Definition

A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.

Chemical Information

Molecular Formula
C25H38O5
Molecular Mass
418.56620
Charge
0
SMILES
CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12
InChI
InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChIKey
RYMZZMVNJRMUDD-HGQWONQESA-N

Alternative Names

  • (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
  • 2,2-dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one
  • MK-733
  • simvastatin
  • Simvastatin
  • Simvastatina
  • Simvastatine
  • Simvastatinum
  • Zocor

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Simvastatin
DRON_00010000
36567
core#notation
CHEBI:9150

Additional References

Wikipedia:Simvastatin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_ndc
24658-501
package_ndc
68382-068-14
listing_expiration_date
20241231
marketing_start_date
19911223
spl_id
06bb9547-b648-4985-b4a1-a5713757b8a8
route
ORAL
package_description
180 TABLET, FILM COATED in 1 BOTTLE (71335-1891-6)
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
SUSPENSION
labeler_name
Salerno Pharmaceuticals Co.
application_number
NDA019766
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Simvastatin
DRON_00010000
36567
oboInOwl#hasAlternativeId
CHEBI:45577
oboInOwl#id
CHEBI:9150
generic_name
SIMVASTATIN
brand_name
ZOCOR
brand_name_base
ZOCOR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_173085
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_40303
manufacturer_name
Salerno Pharmaceuticals Co.
package_marketing_start_date
20241015
active_ingredient_strength
20 mg/5mL
active_ingredient_name
SIMVASTATIN
nui
N0000000121
upc
0372789316901
spl_set_id
8f55d5de-5a4f-4a39-8c84-c53976dd6af9
rxcui
1944266
unii
AGG2FN16EV
core#notation
CHEBI:9150
pharm_class_epc
HMG-CoA Reductase Inhibitor [EPC]
pharm_class
Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
pharm_class_moa
Hydroxymethylglutaryl-CoA Reductase Inhibitors [MoA]
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_0081450
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect38341
owl#annotatedSource
t321270
owl#someValuesFrom
t3005529