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trandolapril

CHEBI:CHEBI_9649

Definition

A heterobicylic compound that is (2S,3aR,7aS)-1-[(2S)-2-aminopropanoyl]octahydro-1H-indole-2-carboxylic acid in which the hydrogen of the amino group is substituted by a (2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl group. It is a angiotensin-converting enzyme inhibitor and a prodrug used for the treatment of hypertension.

Chemical Information

Molecular Formula
C24H34N2O5
Molecular Mass
430.545
Charge
0
SMILES
[H][C@@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC3=CC=CC=C3)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O
InChI
InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
InChIKey
VXFJYXUZANRPDJ-WTNASJBWSA-N

Alternative Names

  • (2S,3aR,7aS)-1-((S)-N-((S)-1-carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid, 1-ethyl ester
  • (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid
  • Gopten
  • Mavik
  • Odrik
  • RU 44570
  • RU-44570
  • RU44570
  • trandolapril
  • trandolaprilum

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Trandolapril
DRON_00010000
38454
core#notation
CHEBI:9649

Additional References

Wikipedia:Trandolapril

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Trandolapril
DRON_00010000
38454
oboInOwl#id
CHEBI:9649
product_type
BULK INGREDIENT
dosage_form
TABLET, FILM COATED, EXTENDED RELEASE
marketing_category
BULK INGREDIENT
labeler_name
Rolabo Outsourcing S.L.
generic_name
Trandolapril and Verapamil Hydrochloride
brand_name
Trandolapril and Verapamil Hydrochloride
brand_name_base
Trandolapril and Verapamil Hydrochloride
product_ndc
68462-294
application_number
ANDA077522
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723853
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_141521
core#notation
CHEBI:9649
rxcui
897853
pharm_class
Calcium Channel Blocker [EPC]
active_ingredient_strength
50 kg/50kg
pharm_class_epc
Angiotensin Converting Enzyme Inhibitor [EPC]
pharm_class_moa
Angiotensin-converting Enzyme Inhibitors [MoA]
active_ingredient_name
TRANDOLAPRIL
unii
1T0N3G9CRC
nui
N0000000181
manufacturer_name
Rising Pharma Holdings, Inc.
spl_set_id
8143a6cf-dadc-4ef7-a8db-d16d7150ad34
upc
0368180568018
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
listing_expiration_date
20241231
route
ORAL
marketing_start_date
20080428
package_marketing_start_date
28-APR-08
spl_id
db3d8012-2159-47f6-8f40-1e86d2d3b8d3
package_ndc
68462-294-90
package_description
90 TABLET, FILM COATED, EXTENDED RELEASE in 1 BOTTLE (68462-294-90)
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect39194
owl#annotatedSource
t324730
owl#someValuesFrom
t2991371