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Trichlormethiazide

CHEBI:CHEBI_9683

Definition

A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.

Chemical Information

Molecular Formula
C8H8Cl3N3O4S2
Molecular Mass
380.658
Charge
0
SMILES
C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O
InChI
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKey
LMJSLTNSBFUCMU-UHFFFAOYSA-N

Alternative Names

  • 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
  • hydrotrichlorothiazide
  • trichlormethiazide
  • trichlormethiazidum
  • triclormetiazida

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Trichlormethiazide
DRON_00010000
10772
core#notation
CHEBI:9683

Additional References

Wikipedia:Trichlormethiazide

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Trichlormethiazide
DRON_00010000
10772
oboInOwl#id
CHEBI:9683
core#notation
CHEBI:9683
generic_name
Trichlormethiazide
listing_expiration_date
20241231
dosage_form
POWDER
active_ingredient_strength
1 kg/kg
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
package_marketing_start_date
16-FEB-17
labeler_name
Derivados Quimicos SAU
marketing_start_date
20140731
product_ndc
59349-0026
spl_id
c8ba3a54-a085-2c9b-e053-2a95a90ac865
active_ingredient_name
TRICHLORMETHIAZIDE
package_ndc
59349-0026-0
package_description
1 BAG in 1 DRUM (59349-0026-0) / 1 BAG in 1 BAG / 25 kg in 1 BAG
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35674
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00000059
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
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t324765
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t930021