ICD-10: M10.219

Drug-induced gout, unspecified shoulder

Additional Information

Description

ICD-10 code M10.219 refers to drug-induced gout, specifically affecting the unspecified shoulder. This classification falls under the broader category of gout, which is a type of inflammatory arthritis characterized by sudden and severe pain, redness, and swelling in the joints. Below is a detailed clinical description and relevant information regarding this condition.

Overview of Drug-Induced Gout

Definition

Drug-induced gout occurs when certain medications lead to an increase in uric acid levels in the blood, resulting in the formation of urate crystals in the joints. This condition can mimic primary gout but is specifically triggered by pharmacological agents.

Common Medications Associated with Drug-Induced Gout

Several classes of medications are known to potentially induce gout, including:

  • Diuretics: Often used to treat hypertension and edema, these can increase uric acid levels by promoting renal excretion of water while retaining uric acid.
  • Chemotherapy agents: Certain cancer treatments can lead to rapid cell turnover, releasing purines that are metabolized to uric acid.
  • Immunosuppressants: Medications like cyclosporine can also elevate uric acid levels.

Clinical Presentation

Symptoms

Patients with drug-induced gout may experience:

  • Acute pain: Sudden onset of severe pain in the shoulder joint, which may be mistaken for other conditions such as rotator cuff injuries.
  • Swelling and redness: The affected area may appear swollen and red, indicating inflammation.
  • Limited range of motion: Pain and swelling can restrict movement in the shoulder.

Diagnosis

Diagnosis typically involves:

  • Clinical evaluation: A thorough history and physical examination to assess symptoms and potential medication use.
  • Laboratory tests: Blood tests to measure uric acid levels, and synovial fluid analysis may be performed to identify urate crystals.
  • Imaging studies: X-rays or ultrasound may be used to evaluate joint damage or inflammation.

Management and Treatment

Immediate Management

  • Medication review: Identifying and potentially discontinuing the offending drug is crucial.
  • Anti-inflammatory medications: Nonsteroidal anti-inflammatory drugs (NSAIDs) or corticosteroids may be prescribed to manage pain and inflammation.

Long-term Management

  • Uric acid-lowering therapy: In cases where gout is recurrent, medications such as allopurinol or febuxostat may be initiated to maintain uric acid levels within a normal range.
  • Lifestyle modifications: Patients are often advised to make dietary changes, such as reducing purine intake, staying hydrated, and avoiding alcohol.

Conclusion

ICD-10 code M10.219 captures the specific scenario of drug-induced gout affecting the shoulder, highlighting the importance of recognizing medication-related triggers in patients presenting with gout symptoms. Effective management involves both addressing the acute symptoms and implementing strategies to prevent future episodes, particularly through careful medication management and lifestyle adjustments. Understanding the nuances of this condition is essential for healthcare providers to deliver appropriate care and improve patient outcomes.

Clinical Information

Overview of Drug-Induced Gout (ICD-10 Code M10.219)

Drug-induced gout is a specific type of gout that occurs as a result of certain medications. It is classified under the ICD-10 code M10.219, which denotes gout that is not specified to a particular joint, in this case, the shoulder. Understanding the clinical presentation, signs, symptoms, and patient characteristics associated with this condition is crucial for effective diagnosis and management.

Clinical Presentation

Patients with drug-induced gout typically present with acute episodes of joint pain, swelling, and inflammation. The condition is characterized by the following features:

  • Acute Onset: Patients often report a sudden onset of severe pain in the affected joint, which can be debilitating.
  • Affected Joint: While the shoulder is specified in this code, gout can affect any joint. In drug-induced cases, the shoulder may be less commonly involved compared to other joints like the big toe or knee.
  • Duration of Symptoms: Episodes can last from a few days to weeks, with varying frequency depending on the underlying cause and the patient's medication regimen.

Signs and Symptoms

The signs and symptoms of drug-induced gout include:

  • Severe Pain: Intense pain in the shoulder joint, often described as throbbing or excruciating, particularly during movement or at night.
  • Swelling and Inflammation: The affected shoulder may appear swollen, red, and warm to the touch, indicating inflammation.
  • Limited Range of Motion: Patients may experience difficulty moving the shoulder due to pain and swelling.
  • Tophi Formation: In chronic cases, deposits of uric acid crystals (tophi) may form, although this is less common in acute drug-induced gout.

Patient Characteristics

Certain patient characteristics can predispose individuals to drug-induced gout:

  • Medication History: Patients taking diuretics, certain chemotherapy agents, or medications that affect uric acid metabolism are at higher risk. Common drugs include thiazide diuretics and some immunosuppressants.
  • Comorbid Conditions: Conditions such as hypertension, diabetes, and renal impairment can increase the likelihood of developing gout.
  • Demographics: Gout is more prevalent in males than females, particularly in middle-aged individuals. However, the incidence in females increases post-menopause.
  • Lifestyle Factors: Obesity, high alcohol consumption, and a diet rich in purines (found in red meat and seafood) can contribute to elevated uric acid levels, exacerbating the risk of gout.

Conclusion

Drug-induced gout, particularly as indicated by ICD-10 code M10.219, presents with acute joint pain, swelling, and inflammation, primarily affecting the shoulder in this context. Understanding the clinical presentation, signs, symptoms, and patient characteristics is essential for healthcare providers to diagnose and manage this condition effectively. Identifying the offending medication and making appropriate adjustments can significantly alleviate symptoms and prevent future episodes. Regular monitoring and patient education on lifestyle modifications are also critical components of managing gout effectively.

Approximate Synonyms

ICD-10 code M10.219 refers to "Drug-induced gout, unspecified shoulder." This code is part of the broader classification of gout-related conditions, specifically indicating that the gout is induced by medication and affects the shoulder area. Below are alternative names and related terms that can be associated with this diagnosis.

Alternative Names for M10.219

  1. Medication-Induced Gout: This term emphasizes that the gout condition is a result of specific medications.
  2. Pharmacological Gout: Similar to medication-induced gout, this term highlights the role of drugs in triggering the condition.
  3. Drug-Related Gout: This phrase can be used interchangeably with drug-induced gout, focusing on the relationship between drug use and the onset of gout symptoms.
  1. Gout: A general term for a type of arthritis characterized by sudden, severe attacks of pain, redness, and tenderness in joints, often starting in the big toe.
  2. Gouty Arthritis: This term refers to the inflammation of joints due to the accumulation of uric acid crystals, which can be precipitated by certain medications.
  3. Shoulder Arthritis: While not specific to gout, this term can describe arthritis affecting the shoulder joint, which may be relevant in the context of M10.219.
  4. Uric Acid Nephropathy: Although primarily related to kidney issues, this term can be relevant as it describes conditions arising from high uric acid levels, which can be influenced by drug use.
  5. Chronic Gout: This term refers to long-term gout conditions, which may be exacerbated by drug interactions.

Contextual Understanding

Understanding the context of M10.219 is crucial for healthcare professionals. Drug-induced gout can occur due to various medications, including diuretics, certain chemotherapy agents, and medications that affect uric acid metabolism. Recognizing the specific drugs involved can help in managing and preventing future gout attacks.

Conclusion

In summary, ICD-10 code M10.219 encompasses various alternative names and related terms that reflect the condition of drug-induced gout affecting the shoulder. Recognizing these terms can aid healthcare providers in accurately diagnosing and treating patients with this specific type of gout. If you need further information on the management or treatment options for drug-induced gout, feel free to ask!

Diagnostic Criteria

To diagnose drug-induced gout, particularly under the ICD-10 code M10.219, healthcare providers follow specific criteria that align with both clinical guidelines and the characteristics of gout itself. Below is a detailed overview of the diagnostic criteria and considerations relevant to this condition.

Understanding Drug-Induced Gout

Gout is a type of inflammatory arthritis characterized by the accumulation of uric acid crystals in the joints, leading to sudden and severe pain, swelling, and redness. Drug-induced gout occurs when certain medications elevate uric acid levels in the body, triggering gout attacks. Common medications associated with this condition include diuretics, certain chemotherapy agents, and immunosuppressants.

Diagnostic Criteria for Drug-Induced Gout

1. Clinical Presentation

  • Acute Gout Attack: Patients typically present with sudden onset of joint pain, often starting at night. The affected joint may be swollen, red, and extremely tender. In the case of M10.219, the unspecified shoulder would be the joint in question.
  • Duration and Frequency: The duration of attacks can vary, but they often last from a few days to weeks. Recurrent attacks may indicate chronic gout.

2. Medical History

  • Medication Review: A thorough review of the patient's medication history is crucial. Identification of drugs known to elevate uric acid levels is essential for establishing a diagnosis of drug-induced gout.
  • Pre-existing Conditions: The presence of other risk factors for gout, such as obesity, renal impairment, or a family history of gout, should also be considered.

3. Laboratory Tests

  • Serum Uric Acid Levels: Elevated serum uric acid levels (hyperuricemia) are a key indicator. While not all patients with high uric acid levels develop gout, levels above 6.8 mg/dL are typically associated with the condition.
  • Joint Aspiration: If feasible, synovial fluid can be aspirated from the affected joint and examined for the presence of monosodium urate crystals, which confirm the diagnosis of gout.

4. Exclusion of Other Conditions

  • Differential Diagnosis: It is important to rule out other causes of joint pain and inflammation, such as infections, other types of arthritis (e.g., rheumatoid arthritis), or trauma. This may involve imaging studies or additional laboratory tests.

5. Response to Treatment

  • Therapeutic Response: A positive response to gout-specific treatments, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or colchicine, can further support the diagnosis.

Conclusion

The diagnosis of drug-induced gout, particularly in the context of the unspecified shoulder, requires a comprehensive approach that includes clinical evaluation, medication history, laboratory tests, and exclusion of other conditions. By adhering to these criteria, healthcare providers can accurately diagnose and manage this painful condition, ensuring appropriate treatment and patient care. If you have further questions or need additional information on this topic, feel free to ask!

Treatment Guidelines

When addressing the treatment of drug-induced gout, particularly as classified under ICD-10 code M10.219, it is essential to understand both the condition itself and the standard treatment approaches. Drug-induced gout occurs when certain medications lead to elevated uric acid levels, resulting in gout attacks. This condition can be particularly challenging when it affects the shoulder, as it may complicate mobility and overall quality of life.

Understanding Drug-Induced Gout

Gout is a form of inflammatory arthritis characterized by sudden and severe pain, redness, and swelling in the joints, often starting in the big toe but can affect other joints, including the shoulder. Drug-induced gout can be triggered by medications that increase uric acid levels, such as diuretics, certain chemotherapy agents, and some immunosuppressants[1].

Standard Treatment Approaches

1. Medication Management

The primary goal in treating drug-induced gout is to manage pain and inflammation while addressing the underlying cause of elevated uric acid levels. Common treatment options include:

  • Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Medications like ibuprofen or naproxen are often prescribed to reduce pain and inflammation during acute gout attacks[2].

  • Colchicine: This medication can be effective in treating acute gout attacks and may also be used for prophylaxis in patients with recurrent episodes[3].

  • Corticosteroids: For patients who cannot tolerate NSAIDs or colchicine, corticosteroids may be administered either orally or via injection to reduce inflammation[4].

  • Urate-Lowering Therapy: Long-term management may involve medications such as allopurinol or febuxostat, which help lower uric acid levels in the blood and prevent future attacks[5].

2. Identifying and Modifying Triggering Medications

A critical aspect of managing drug-induced gout is identifying the offending medication. Healthcare providers may review the patient's medication list and consider alternatives to drugs that contribute to elevated uric acid levels. For instance, switching from a thiazide diuretic to a potassium-sparing diuretic may be beneficial[6].

3. Lifestyle Modifications

In addition to pharmacological treatments, lifestyle changes can significantly impact the management of gout:

  • Dietary Adjustments: Patients are often advised to limit purine-rich foods (e.g., red meat, shellfish) and alcohol, which can exacerbate gout symptoms[7].

  • Hydration: Increasing fluid intake helps dilute uric acid levels and promotes its excretion through the kidneys[8].

  • Weight Management: Maintaining a healthy weight can reduce the frequency of gout attacks and improve overall joint health[9].

4. Physical Therapy

For patients experiencing shoulder involvement, physical therapy may be recommended to improve joint function and reduce stiffness. A physical therapist can design a tailored exercise program that focuses on range of motion and strengthening exercises[10].

Conclusion

Managing drug-induced gout, particularly when it affects the shoulder, requires a multifaceted approach that includes medication management, lifestyle modifications, and possibly physical therapy. Identifying and addressing the underlying causes, particularly the medications that trigger elevated uric acid levels, is crucial for effective treatment. Patients should work closely with their healthcare providers to develop a comprehensive management plan tailored to their specific needs and circumstances.

By understanding the complexities of drug-induced gout and implementing appropriate treatment strategies, individuals can achieve better control over their symptoms and improve their quality of life.


References

  1. [1] Overview of drug-induced gout and its causes.
  2. [2] Role of NSAIDs in managing gout attacks.
  3. [3] Efficacy of colchicine in acute gout treatment.
  4. [4] Use of corticosteroids for gout management.
  5. [5] Long-term urate-lowering therapy options.
  6. [6] Importance of reviewing and modifying triggering medications.
  7. [7] Dietary recommendations for gout patients.
  8. [8] Hydration's role in uric acid management.
  9. [9] Impact of weight management on gout frequency.
  10. [10] Benefits of physical therapy for joint health.

Related Information

Description

  • Drug-induced gout occurs when medications increase uric acid levels
  • Certain medications can lead to an increase in uric acid levels
  • Diuretics, chemotherapy agents, and immunosuppressants are common culprits
  • Acute pain, swelling, and redness are common symptoms
  • Limited range of motion due to pain and swelling is possible
  • Medication review and discontinuation is crucial for management
  • Anti-inflammatory medications may be prescribed for pain relief

Clinical Information

  • Sudden onset of severe joint pain
  • Swelling and inflammation in affected joint
  • Limited range of motion due to pain and swelling
  • Tophi formation in chronic cases is rare
  • Medications like diuretics increase gout risk
  • Comorbid conditions like hypertension contribute to gout
  • Males are more prone to gout than females

Approximate Synonyms

  • Medication-Induced Gout
  • Pharmacological Gout
  • Drug-Related Gout
  • Gouty Arthritis
  • Shoulder Arthritis

Diagnostic Criteria

  • Sudden onset of joint pain at night
  • Swollen, red, extremely tender joint
  • Duration of attacks can vary from days to weeks
  • Recurrent attacks may indicate chronic gout
  • Medications known to elevate uric acid levels
  • Pre-existing conditions such as obesity or renal impairment
  • Elevated serum uric acid levels (hyperuricemia)
  • Presence of monosodium urate crystals in synovial fluid
  • Positive response to gout-specific treatments

Treatment Guidelines

  • Identify triggering medications
  • Switch to alternative medications
  • Use NSAIDs for pain relief
  • Administer colchicine for acute attacks
  • Prescribe corticosteroids for inflammation
  • Initiate urate-lowering therapy
  • Promote hydration and fluid intake
  • Encourage dietary adjustments
  • Support weight management efforts
  • Recommend physical therapy for joint mobility

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