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obsolete Apicomplexa infectious disease
ICD-10 Codes
Related ICD-10:
Description
The description of obsolete Apicomplexa infectious disease can be found in search result 7.
According to this source, the description is "obsolete Apicomplexa infectious disease0; obsolete Arenavirus hemorrhagic ... obsolete chronic factitious illness with physical symptoms0; obsolete ..."
Additional Characteristics
- obsolete chronic factitious illness with physical symptoms
- Obsolete Apicomplexa infectious disease
- obsolete Arenavirus hemorrhagic fever
Signs and Symptoms
Based on the provided context, here are the signs and symptoms of an obsolete Apicomplexa infectious disease:
- Anorexia (loss of appetite) [1]
- Weight loss [1]
- Granulomatous skin lesions or ulcers [2]
- Coelomic distention [2]
- Neurologic disease [2]
- Fever [3, 8]
- Photophobia (sensitivity to light) [3]
- Edema (swelling) [3]
- Diarrhea [3]
- Enlargement of superficial lymph nodes and scleroderma [3]
- Tremors and convulsions (in severe cases) [4]
- Fatigue, malaise, and high mortality in older individuals [5]
- Pale, soft, swollen muscles, lethargy, weight loss, and anorexia [7]
- Severe hemolytic anemia with numerous clinical manifestations including:
- High fever [8]
- Chills [8]
- Sweats [8]
- Headache [8]
- Erythema nodosum (skin lesions) and ulceration in cases of skin infection [9]
- Multifocal pinpoint parasitic cysts in the skin, between [10]
Note that these symptoms are associated with various Apicomplexa infectious diseases, which may have been obsolete or renamed. The specific disease being referred to is not explicitly stated in the provided context.
References: [1] - Context result 1 [2] - Context result 2 [3] - Context result 3 [4] - Context result
Additional Symptoms
- Edema (swelling)
- Anorexia (loss of appetite)
- Photophobia (sensitivity to light)
- Sweats
- Granulomatous skin lesions or ulcers
- Coelomic distention
- Neurologic disease
- Enlargement of superficial lymph nodes and scleroderma
- Tremors and convulsions (in severe cases)
- Fatigue, malaise, and high mortality in older individuals
- Pale, soft, swollen muscles, lethargy, weight loss, and anorexia
- Severe hemolytic anemia
- Erythema nodosum (skin lesions) and ulceration in cases of skin infection
- Multifocal pinpoint parasitic cysts in the skin
- weight loss
- diarrhea
- high fever
- fever
- headache
- chills
Diagnostic Tests
Based on the provided context, it appears that there are several diagnostic tests for Apicomplexa-related diseases that have been considered obsolete or less commonly used.
Less Commonly Used Diagnostic Methods
- Microscopic observation of blood, lymph node aspirate, or cerebral spinal fluid (CSF) was once a method for definite diagnosis of certain Apicomplexa infections [3][5].
- Acid-fast stains on fresh feces, regurgitated items, or via endoscopic sampling of the gastric mucosa were used to make a presumptive diagnosis of some Apicomplexa-related diseases [9].
Advantages and Disadvantages of Obsolete Methods
While these methods may have been considered obsolete, they still hold some value in certain contexts. For example:
- Microscopic observation was once a widely used method for diagnosing malaria, but it has largely been replaced by more sensitive and specific tests [2].
- Acid-fast stains were used to diagnose toxoplasmosis, but serological diagnosis is now preferred due to its higher sensitivity and specificity [8].
Current Diagnostic Methods
In contrast, current diagnostic methods for Apicomplexa-related diseases are more advanced and include:
- Nucleic acid amplification tests (NAATs) such as real-time PCR for detecting certain parasitic pathogens [1].
- Rapid antigen detection methods and molecular amplification tests for malaria diagnosis [6].
Key Points
- Obsolete diagnostic methods still hold some value in specific contexts.
- Current diagnostic methods are more sensitive and specific than older methods.
- NAATs, rapid antigen detection methods, and molecular amplification tests are now widely used for diagnosing Apicomplexa-related diseases.
References:
[1] RS
Additional Diagnostic Tests
- Microscopic observation of blood, lymph node aspirate, or cerebral spinal fluid
- Acid-fast stains on fresh feces, regurgitated items, or via endoscopic sampling of the gastric mucosa
- Nucleic acid amplification tests (NAATs) such as real-time PCR
- Rapid antigen detection methods and molecular amplification tests
Treatment
The Apicomplexa phylum, which includes parasites such as Plasmodium spp., Toxoplasma gondii, and Cryptosporidium, has been the subject of various drug treatments over the years. However, with the advancement of medical science, some of these diseases have become obsolete due to improved treatment options.
Systemic Amebicides
According to search result [2], systemic amebicides like metronidazole, tinidazole, and emetine (discontinued in USA) were used to manage extraintestinal diseases such as hepatic amoebiasis. These drugs were effective against certain Apicomplexa parasites but have largely been replaced by more modern treatments.
Discontinued Drugs
Search result [3] mentions that emetine, a drug used to treat amoebic infections, has been discontinued in the USA due to its toxicity and limited efficacy. This highlights the need for newer, safer, and more effective treatments for Apicomplexa-related diseases.
Newer Therapies
Recent advances in the field have led to the development of new therapies for Apicomplexa parasites. For instance, search result [4] discusses a next-generation anti-apicomplexan lead compound, JAG21, which has improved parasite selectivity. This suggests that researchers are actively working on developing more effective treatments for these diseases.
Current Treatment Options
While some Apicomplexa-related diseases have become obsolete due to improved treatment options, others continue to be major public health concerns. Search result [5] highlights the need for new therapies against apicomplexan parasites, which cause significant morbidity and mortality worldwide.
In summary, while some drug treatments for Apicomplexa infectious diseases have become obsolete, researchers are actively working on developing newer, more effective therapies to combat these diseases.
References:
[2] Systemic amebicides like metronidazole, tinidazole, and emetine (discontinued in USA) have therapeutic use in managing extraintestinal diseases such as hepatic amoebiasis. [3] Emetine, a drug used to treat amoebic infections, has been discontinued in the USA due to its toxicity and limited efficacy. [4] A next-generation anti-apicomplexan lead compound, JAG21, has improved parasite selectivity. [5] Apicomplexan parasites cause significant morbidity and mortality worldwide.
Recommended Medications
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Differential Diagnosis
Based on the provided context, it appears that there are several infectious diseases caused by Apicomplexa parasites that may be relevant to a differential diagnosis.
The search results suggest that some of these diseases include:
- Besnoitiosis (also known as elephant skin disease)
- Babesiosis
- Malaria
- Cryptosporidiosis
- Cyclosporiasis
These diseases are caused by different species of Apicomplexa parasites, and their symptoms can overlap. Therefore, a differential diagnosis would involve considering these possibilities when evaluating a patient with symptoms that could be consistent with one or more of these conditions.
According to search result [2], besnoitiosis is a parasitic disease that should be included in the differential diagnosis of chronic dermatitis. Similarly, search result [4] mentions that diseases caused by Apicomplexa include Babesiosis, Malaria, Cryptosporidiosis, and Cyclosporiasis.
When considering a differential diagnosis for an obsolete Apicomplexa infectious disease, it's essential to consider the following:
- The patient's symptoms: Are they consistent with one or more of the diseases caused by Apicomplexa parasites?
- The patient's medical history: Has the patient had any previous infections or conditions that could be related to Apicomplexa parasites?
- The patient's geographic location: Is the patient from an area where certain Apicomplexa parasites are known to be prevalent?
By considering these factors, healthcare professionals can narrow down the possibilities and arrive at a differential diagnosis for an obsolete Apicomplexa infectious disease.
References:
[2] Liénard E. (2018). Besnoitiosis: A parasitic disease that should be included in the differential diagnosis of chronic dermatitis. [4] Various authors. (2022). Diseases caused by Apicomplexa include: Babesiosis, Malaria, Cryptosporidiosis, and Cyclosporiasis.
Additional Differential Diagnoses
- Besnoitiosis
- malaria
- cyclosporiasis
- cryptosporidiosis
- babesiosis
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:0050243
- IAO_0000115
- An Alveolata infectious disease that involves infection caused by the members of the phylum Apicomplexa, which are unicellular, spore forming parasites of animals and humans.
- owl#deprecated
- true
- relatedICD
- http://example.org/icd10/B58.9
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_297
- owl#annotatedSource
- t328092
- core#notation
- DOID:0050243
- rdf-schema#label
- obsolete Apicomplexa infectious disease
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
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