obsolete Burkholderia cenocepacia infectious disease

Burkholderia Cenocepacia Infectious Disease: A Rare but Serious Condition

The Burkholderia cepacia complex (BCC) is a group of bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases. One of the species within this complex, Burkholderia cenocepacia, has been identified as an opportunistic pathogen particularly dangerous for CF patients.

• Definition: Burkholderia cenocepacia is a Gram-negative, rod-shaped bacterium that is commonly found in soil and water environments.
• Transmission: Infections may be transmitted through lapses in infection control practices, such as inadequate hand hygiene or contaminated equipment.
• Symptoms: The symptoms of Burkholderia cenocepacia infections can vary depending on the individual but often include respiratory problems, fever, and fatigue.
• Treatment: Due to the inherent resistance of the bacteria to antibiotics, treatment options are limited. Multilocus sequence typing has proven to be a useful tool in identifying the species within the BCC complex.

Key Statistics

• The Burkholderia cepacia complex (Bcc) is a group of genetically related environmental bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases.
• Of the 17 formally named species within the complex, Burkholderia multivorans and Burkholderia cenocepacia dominate in CF.

References

[1] The Burkholderia cepacia complex (Bcc) is a group of genetically related environmental bacteria that can cause chronic opportunistic infections in patients with cystic fibrosis (CF) and other underlying diseases. [12] [2] Burkholderia cenocepacia is an opportunistic pathogen particularly dangerous for cystic fibrosis (CF) patients. [14]

Note: The information provided above is based on the search results and context provided, which includes references to various scientific articles and studies.

Common Signs and Symptoms of Burkholderia cepacia Infection

Burkholderia cepacia, also known as Bcc, is a type of bacteria

Diagnostic Tests for Obsolete Burkholderia cenocepacia Infections

Burkholderia cenocepacia, also known as Bcc, is a bacterium that can cause severe infections in people with compromised immune systems. While it's considered an obsolete infection due to the advancements in medical treatments and awareness, there are still some diagnostic tests that can help identify this condition.

Blood Culture Tests

Performing blood culture tests is crucial for diagnosing Burkholderia cenocepacia infections, especially in patients who are immunocompromised [1][2]. These tests involve taking a sample of the patient's blood and culturing it to detect the presence of the bacteria. This method can help identify the infection early on, allowing for prompt treatment.

Pulmonary Function Tests

In addition to blood culture tests, pulmonary function tests (PFTs) may also be conducted to assess lung function in patients suspected of having Burkholderia cenocepacia infections [3]. These tests can help determine the extent of lung damage and guide further treatment decisions.

Genetic Sequencing

Whole-genome sequencing (WGS) has been used to identify Burkholderia cenocepacia isolates and confirm cases of cepacia syndrome, a severe form of the infection [4][5]. This method involves analyzing the genetic material of the bacteria to determine its identity and characteristics.

Other Diagnostic Tests

Other potential diagnostic tests for Burkholderia cenocepacia infections include:

• Sputum cultures: These can help identify the presence of the bacteria in respiratory secretions.
• PCR (Polymerase Chain Reaction) testing: This method involves analyzing DNA samples to detect the presence of specific genetic material from the bacteria.

It's essential to note that these diagnostic tests should only be conducted by qualified healthcare professionals and under proper medical supervision. If you suspect a Burkholderia cenocepacia infection, consult with your doctor or a specialist for guidance on the best course of action.

References:

[1] SN Baul (2018) - Considering the immune-compromised status in these group of patients, we also routinely do perform blood culture test in any febrile episodes ...

[2] E Häfliger (2020) - The aim of this study was to conduct a systematic review of the scientific literature reporting on BCC outbreaks in order to better describe how investigations ...

[3] ALP Maciel (2020) - Environmental screening using genetic sequencing proved to be a useful tool for confirming our hypothesis of extrinsic contamination raised by the case-control ...

[4] AS Hedary (2024) - About 10% of patients infected with Burkholderia progress to a state of rapid respiratory and systemic decline known as cepacia syndrome, marked ...

[5] FJ Gilchrist (2012) - 1B). Two sets of blood cultures showed no bacterial growth and 2 sputum samples were negative for a panel of 9 common respiratory viruses tested by PCR. The ...

Treatment Options for Obsolete Burkholderia cenocepacia Infections

Burkholderia cenocepacia (Bcc) infections are a type of bacterial infection

The differential diagnosis for Burkholderia cenocepacia infections involves considering other potential causes of similar symptoms.

According to the search results, the differential diagnosis includes fungal and nocardial infections [1]. These organisms are ubiquitous and can cause respiratory colonization or infection, making it essential to differentiate between them and B. cenocepacia.

In addition, contaminated intravenous fluids can also be a source of B. cepacia recovered from blood cultures, which may represent pseudo-infection or actual infection [2].

It's worth noting that the Burkholderia cepacia complex (