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Colistin

CHEBI:CHEBI_37943

Definition

A multi-component mixture comprising mostly of colistin A (R = Me) and B (R = H), with small amounts of colistin C and other polymyxins, produced by certain strains of Bacillus polymyxa var. colistinus. An antibiotic, it is used as its sulfate salt (for oral or topical use) or as the sodium salt of the N-methylsulfonic acid derivative (the injectable form) in the treatment of severe Gram-negative infections, partiularly those due to Pseudomonas aeruginosa.

Chemical Information

Molecular Formula
C52H97N16O13R
Molecular Mass
1154.428
Charge
0
SMILES
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCN)=O)CCN)=O)CC(C)C)=O)CC(C)C)=O)CCN)=O)=O)CCN)=O)[C@@H](C)O)=O)CCN)=O)CCC[C@@H](C*)C

Alternative Names

  • Colistin
  • colistina
  • colistine
  • colistinum
  • polymyxin E

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
2709
oboInOwl#hasDbXref
PMID:28321410
core#notation
CHEBI:37943

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
2709
oboInOwl#hasDbXref
PMID:28321410
oboInOwl#hasAlternativeId
CHEBI:659853
oboInOwl#id
CHEBI:37943
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
dosage_form
SUSPENSION
route
AURICULAR (OTIC)
marketing_start_date
19980901
package_marketing_start_date
07-DEC-20
labeler_name
Xellia Pharmaceuticals ApS
manufacturer_name
Endo USA, Inc.
generic_name
Colistin Sulfate
brand_name
Cortisporin TC
brand_name_base
Cortisporin TC
product_ndc
45932-0003
application_number
NDA050356
spl_id
80cd18c2-7263-4d34-be31-fa6dd1db53e4
package_ndc
45932-0003-2
package_description
1.5 kg in 1 CONTAINER (45932-0003-2)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50909
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_59673
core#notation
CHEBI:37943
rxcui
854997
pharm_class
Aminoglycosides [CS]
active_ingredient_strength
3.3 mg/mL
active_ingredient_name
THONZONIUM BROMIDE
unii
JI2B19CR0R
spl_set_id
9c6fc1c7-3350-42ae-b999-aca48e704bb1
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http://www.w3.org/2002/07/owl#Class
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http://purl.obolibrary.org/obo/DOID_5053
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https://w3id.org/def/predibionto#has_side_effect22942
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t899320