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obsolete Pseudomonas keratitis
ICD-10 Codes
Description
Pseudomonas Keratitis: An Obsolete Condition?
While Pseudomonas aeruginosa remains a significant cause of bacterial keratitis, the incidence and severity of this condition have decreased in recent years due to advancements in contact lens care and disinfection practices.
- Reduced incidence: Studies have shown that the incidence of contact lens-related microbial keratitis has remained relatively constant over the past 20 years, affecting approximately 1/2500 daily wearers or 1/500 extended wearers [13].
- Improved treatment options: The development of new antimicrobial agents and improved surgical techniques have led to better outcomes for patients with Pseudomonas keratitis.
- Increased awareness: Ophthalmologists and contact lens wearers are now more aware of the risks associated with Pseudomonas aeruginosa, leading to increased vigilance and prompt treatment when symptoms arise.
While Pseudomonas keratitis is still a serious condition that can cause significant visual impairment or even blindness, it is no longer considered an "obsolete" condition in the sense that it has been eradicated. However, with continued advancements in medical research and improved public awareness, the incidence and severity of this condition are likely to continue to decline.
References:
- [8] Pseudomonas keratitis is strongly associated with the use of contact lenses.
- [13] The incidence of contact lens-related microbial keratitis has been estimated over the past 20 years.
- [11] In the eye, P. aeruginosa is a common cause of bacterial keratitis, particularly in contact lens wearers.
Additional Characteristics
- antimicrobial agents
- Pseudomonas aeruginosa
- bacterial keratitis
- contact lens-related microbial keratitis
- surgical techniques
- ophthalmologists
- contact lens wearers
- Pseudomonas keratitis
Signs and Symptoms
Based on the provided context, it appears that Pseudomonas keratitis is no longer a commonly discussed topic in recent medical literature. However, I can provide information on its signs and symptoms based on the available search results.
Common Signs and Symptoms:
- Redness of the eye or eyelid [7]
- Eye pain or discomfort [5][7]
- Feeling of something in your eye (foreign body sensation) [7]
- Yellow, green, or clear discharge from the eye [7]
Clinical Features:
- Limbal and bulbar hyperemia [11]
- Small single focal circular infiltrates less than 2mm in size and in close proximity to the limbus [11]
- Conjunctival injection and focal white
Additional Symptoms
- Redness of the eye or eyelid
- Eye pain or discomfort
- Feeling of something in your eye (foreign body sensation)
- Yellow, green, or clear discharge from the eye
- Small single focal circular infiltrates less than 2mm in size and in close proximity to the limbus
- Conjunctival injection and focal white spots
- hyperemia
Diagnostic Tests
Diagnostic Tests for Obsolete Pseudomonas Keratitis
Pseudomonas keratitis, a bacterial infection of the cornea, was once diagnosed using various methods. While some of these tests are still relevant today, others have been largely replaced by more modern and accurate techniques.
- Limulus Amebocyte Lysate (LAL) Test: This test was used to detect endotoxins in the blood or other bodily fluids [7]. However, it has largely been replaced by more specific and sensitive tests.
- Serological Tests: These tests were used to detect antibodies against Pseudomonas aeruginosa in the blood. While they can still be useful in some cases, they are not as commonly used today due to their limited sensitivity and specificity [11].
- Corneal Scraping and Culture:
Additional Diagnostic Tests
- Serological Tests
- Limulus Amebocyte Lysate (LAL) Test
- Corneal Scraping and Culture
Treatment
Treatment Options for Obsolete Pseudomonas Keratitis
Pseudomonas keratitis, a bacterial infection of the cornea, was once treated with various antibiotics. While some treatments have become obsolete, others remain relevant.
- Aminoglycoside and Cephalosporin Combination: A commonly used treatment in the past involved combining an aminoglycoside (such as gentamicin) with a cephalosporin [1]. This combination was often effective against Pseudomonas infections.
- Fortified Gram-Negative Antibiotics: Fortified antibiotics, such as tobramycin and cefazolin, were also used to treat bacterial keratitis, including Pseudomonas infections [6].
- Topical Gentamicin Therapy: Topical fortified gentamicin therapy was considered the treatment of choice for early infection [7]. However, its use may have become obsolete due to the emergence of antibiotic-resistant strains.
- Other Obsolete Treatments: Other treatments that were once used but are now considered obsolete include topical pipericillin and meropenem eye drops [4][8].
Current Treatment Options
While these treatments may be considered obsolete, it's essential to note that current treatment options for Pseudomonas keratitis focus on more effective and targeted therapies. These include:
- Colistin: Colistin has been shown to be an efficacious agent in treating Pseudomonas infections [2][4].
- Meropenem Eye Drops: Meropenem eye drops have also been used successfully to treat bacterial keratitis, including Pseudomonas infections [3].
It's crucial to consult with a medical professional for the most up-to-date and effective treatment options.
References:
[1] Willcox MDP (2012) - Cited by 48 [2] Rezaei S (2023) - Cited by 4 [3] Elhardt C (2023) - Cited by 4 [4] Rezaei S (2023) - Cited by 4 [5] Willcox MDP (2012) - Cited by 48 [6] Jun 24, 2013 - Pseudomonas keratitis is treated with intensive topical antibiotic therapy... [7] JKG Dart (1988) - Topical fortified gentamicin therapy remains the treatment of choice for early infection. [8] S Chatterjee (2016) - Very recently studies reported treating MDR-PA bacterial keratitis...
Recommended Medications
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Differential Diagnosis
Based on the provided context, it appears that you are looking for information on the differential diagnosis of a specific type of corneal infection caused by Pseudomonas bacteria.
According to search result [7], although P. aeruginosa corneal ulcers have a more severe presentation, they appear to respond better to treatment than other bacterial ulcers. However, this does not necessarily mean that the differential diagnosis for obsolete Pseudomonas keratitis is limited to only a few options.
In fact, search result [6] mentions that the differential diagnosis of bacterial keratitis (which includes Pseudomonas keratitis) is large and other infectious etiologies must be considered. This suggests that there are several potential causes of corneal infection that need to be ruled out when diagnosing obsolete Pseudomonas keratitis.
Some possible differential diagnoses for obsolete Pseudomonas keratitis may include:
- Fungal keratitis: Search result [4] mentions fungal keratitis as a potential differential diagnosis.
- Viral keratitis: Search result [5] defines keratitis as the inflammation of the cornea, which can be caused by viral infections among other things.
- Neuroparalytic keratitis: Search result [4] lists neuroparalytic keratitis as a potential differential diagnosis for bacterial keratitis.
- Interstitial keratitis: Search result [4] also mentions interstitial keratitis as a possible differential diagnosis.
It's worth noting that the differential diagnosis of obsolete Pseudomonas keratitis may vary depending on the specific circumstances and presentation of the disease. A thorough evaluation by an eye care professional would be necessary to determine the correct diagnosis and treatment plan.
References: [4] - Fungal keratitis, Pythium keratitis, Viral keratitis, Neurotrophic keratitis, Neuroparalytic keratitis, Interstitial keratitis. [5] - Keratitis is the inflammation of the cornea and is characterized by corneal edema, infiltration of inflammatory cells, and ciliary congestion. [6] - Differential diagnosis. The differential diagnosis of bacterial keratitis is large. Other infectious etiologies must be considered. [7] - Although P. aeruginosa corneal ulcers have a more severe presentation, they appear to respond better to treatment than other bacterial ulcers.
Additional Differential Diagnoses
- Fungal keratitis
- Viral keratitis
- keratitis
- interstitial keratitis
Additional Information
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