infiltrating renal pelvis transitional cell carcinoma

Characteristics of Infiltrating Renal Pelvis Transitional Cell Carcinoma

Infiltrating renal pelvis transitional cell carcinoma, also known as urothelial carcinoma, is a type of cancer that affects the lining of the kidney's renal pelvis and ureter. The following are some key characteristics of this condition:

• Location: This cancer typically arises in the renal pelvis and can spread to other parts of the urinary system.
• Type: It is a rare type of upper urinary tract urothelial cancer, previously known as transitional cell cancer (TCC) of the kidney or ureter.
• Spread: Infiltrating renal pelvis transitional cell carcinoma can metastasize to other areas, making it essential for early detection and treatment.

Key Features

• The cancer often starts in the renal pelvis and can spread outwards, infiltrating the renal parenchyma while preserving its contour.
• On unenhanced computed tomography (CT) scans, this type of cancer may appear as a solid, albeit hypoechoic mass located within the renal pelvis or a dilated ureter.

Prognosis

• If detected early and confined to the renal pelvis or ureter, more than 90% of patients can be cured.
• However, if left untreated or diagnosed at a later stage, the cancer's prognosis worsens.

These characteristics are based on information from various medical sources, including:

• [1] - Transitional cell carcinomas appear as solid, albeit hypoechoic masses located within the renal pelvis or a dilated ureter.
• [2] - These cancers are curable in more than 90% of patients if they are superficial and confined to the renal pelvis or ureter.
• [3] - These cancers are curable in more than 90% of patients if they are superficial and confined to the renal pelvis or ureter.
• [5] - Urothelial carcinoma (also called transitional cell carcinoma) is a cancerous tumour of the renal pelvis and ureter that can spread (metastasize) to other parts...
• [8] - Urothelial carcinoma (also called transitional cell carcinoma) is a cancerous tumour of the renal pelvis and ureter that can spread (metastasize) to other...
• [9] - Renal TCC most frequently arises in the renal pelvis, and spreads outwards, infiltrating the renal parenchyma but preserving its contour. On unenhanced...

Based on the provided context, here are the signs and symptoms of infiltrating renal pelvis transitional cell carcinoma:

• Persistent back pain [10]
• Tiredness [10]
• Unexplained weight loss [10]
• Painful urination (dysuria) [10]
• A lump or mass in the affected area [10]

Additionally, other symptoms may include:

• Blood in the urine, which may make it look red, pink, or cola-colored [12]
• Back pain [12]

It's worth noting that these symptoms can also be indicative of other conditions, and a proper diagnosis should only be made by a qualified medical professional. If you suspect you have this condition, please consult a doctor for further evaluation.

References: [10] - Context result 10 [12] - Context result 12

To diagnose infiltrating renal pelvis transitional cell carcinoma, various tests can be employed.

Imaging Studies

• Abdominal ultrasound is often used to help diagnose cancer of the renal pelvis and ureter [7].
• Magnetic resonance imaging (MRI) may also be performed to aid in diagnosis [7].

Endoscopic Procedures

• Ureteroscopy is a routine diagnostic tool for renal pelvic tumors, with a correct diagnosis achieved in 80-90% of cases [2]. During this procedure, a thin instrument with a lighted lens, called a ureteroscope, is used to examine the renal pelvis for any abnormalities.
• Ureteropyeloscopy combined with cytology and biopsy may also be employed as a diagnostic tool [8].

Laboratory Tests

• A urinalysis may be ordered to check for blood, protein, and bacteria in the urine. Based on the results of these tests, additional tests such as intravenous urography or computed tomography (CT) scans may be recommended [5].
• Laboratory studies, including cytology, are also used to diagnose renal cell carcinoma [9].

Other Diagnostic Tools

• Excretory urography and retrograde pyelography are conventional diagnostic tools that can aid in the diagnosis of cancer of the renal pelvis and ureter [8].
• Computed Tomography (CT) scans may be performed to help diagnose cancer of the renal pelvis and

Based on the provided context, it appears that the primary treatment for infiltrating renal pelvis transitional cell carcinoma involves surgery, specifically total nephroureterectomy with bladder cuff excision [1]. However, in cases of metastatic or recurrent disease, chemotherapy and immunotherapy may be considered as alternative treatment options.

Chemotherapy is a common approach for treating this type of cancer, and the most commonly used regimen is gemcitabine with cisplatin (GC) [4][9]. This combination has been shown to be effective in reducing tumor size and improving patient outcomes. Additionally, local immunotherapy or chemotherapy can be attempted as an independent treatment method in cases of carcinoma in situ (CIS) or to reduce the recurrence rate [3].

It's worth noting that kidney-sparing surgery is also being explored as a primary treatment option for low-risk tumors, but this approach may not be suitable for all patients with infiltrating renal pelvis transitional cell carcinoma [7]. The decision on the most appropriate treatment plan should be made in consultation with a healthcare professional.

References: [1] Jan 5, 2024 — Most patients with renal pelvic transitional cell cancers and ureteral cancers undergo total nephroureterectomy with bladder cuff excision. [3] Jun 13, 2022 — Local immunotherapy or chemotherapy can be attempted as an independent treatment method in cases of carcinoma in situ (CIS) or to reduce the recurrence rate. [4] Mar 28, 2024 — The main treatments are chemotherapy and immunotherapy. Chemotherapy. You may have either: gemcitabine with cisplatin (GC); gemcitabine with ... [7] Apr 7, 2023 — The EAU recommends offering kidney-sparing surgery as the primary treatment option for these low-risk tumors. [9] Jan 5, 2024 — Total excision of the ureter with a bladder cuff, renal pelvis, and kidney is recommended to provide the greatest likelihood of cure.

The differential diagnosis for infiltrating renal pelvis transitional cell carcinoma (TCC) involves a range of conditions that can present with similar symptoms and radiographic appearances.

Key considerations:

• Renal Cell Carcinoma (RCC): RCC is a common type of kidney cancer that can also present as an infiltrative mass in the renal pelvis. The differential diagnosis between RCC and TCC can be challenging, especially when the tumor center is located within the renal parenchyma [6].
• Metastasis to the kidney: Metastatic lesions from other primary cancers can also mimic the appearance of a primary renal tumor, including TCC.
• Central Transitional Cell Carcinoma (TCC): Central TCC is a type of TCC that arises in the renal pelvis and can infiltrate into the surrounding parenchyma. The differential diagnosis for central TCC includes RCC, metastasis to the kidney, and other benign or malignant entities [5].
• Sarcomatoid renal tumors: Sarcomatoid renal tumors are a rare type of cancer that can also present as an infiltrative mass in the renal pelvis.
• Secondary invasion by clear cell RCC: Clear cell RCC is a common type of RCC that can invade into the renal pelvis, making it difficult to distinguish from primary TCC [9].

Diagnostic approaches:

• Imaging studies: Imaging studies such as CT scans and MRI can help to differentiate between these conditions based on their radiographic appearance.
• Biopsy and histopathology: A biopsy and histopathological examination of the tumor tissue can provide a definitive diagnosis.

In conclusion, the differential diagnosis for infiltrating renal pelvis TCC is complex and requires a thorough evaluation of clinical presentation, imaging studies, and histopathological findings.