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integumentary system benign neoplasm
ICD-10 Codes
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Description
A benign neoplasm of the integumentary system refers to a non-cancerous growth or tumor that occurs in the skin or its associated tissues.
- These growths are typically soft, pale yellow, and shiny bumps that appear on the forehead, cheeks, or near hair follicles.
- They are usually asymptomatic, meaning they do not cause any discomfort or pain.
- Benign neoplasms of the integumentary system are characterized by the absence of atypical or malignant cytological and architectural features.
Some common types of benign neoplasms that affect the integumentary system include:
- Sebaceous hyperplasia: a condition where there is an overgrowth of sebaceous glands, leading to the formation of small, pale yellow bumps on the skin.
- Lipomas: benign tumors made up of fat cells that can appear anywhere on the body.
- Dermatofibromas: small, firm bumps that typically appear on the legs or arms.
These growths are usually harmless and do not require treatment unless they become cosmetically bothersome or cause other symptoms. In such cases, excision (removal) of the neoplasm is often the recommended course of action.
Sources:
- [1] Sebaceous hyperplasia presents as asymptomatic, discrete, soft, pale yellow, shiny bumps on the forehead or cheeks, or near hair follicles.
- [4] Mondo Description A benign neoplasm that involves the integumental system. Mondo Term and Equivalent IDs. MONDO:0000652: integumentary system benign neoplasm.
- [5] Generally, excision is the treatment of choice for lipomas, dermatofibromas, keratoacanthomas, pyogenic granulomas, and epidermoid cysts.
Additional Characteristics
- A non-cancerous growth or tumor that occurs in the skin or its associated tissues
- Soft, pale yellow, and shiny bumps on the forehead, cheeks, or near hair follicles
- Asymptomatic, meaning they do not cause any discomfort or pain
- Sebaceous hyperplasia: a condition where there is an overgrowth of sebaceous glands
- Lipomas: benign tumors made up of fat cells that can appear anywhere on the body
- Dermatofibromas: small, firm bumps that typically appear on the legs or arms
- Generally, excision is the treatment of choice for lipomas, dermatofibromas
Signs and Symptoms
Based on the context provided, here are some signs and symptoms of integumentary system benign neoplasms:
- New bumps or patches on the skin
- Changes in the size, shape, or color of skin growths
- Asymptomatic, discrete, soft, pale yellow, shiny bumps on the forehead or cheeks (sebaceous hyperplasia)
- Skin tags
- Moles that multiply or darken over time
- Seborrheic keratoses (may appear as brown, black, or tan spots)
Note: These symptoms are generally associated with benign skin growths and neoplasms. If you're concerned about a specific symptom or growth, it's always best to consult a healthcare professional for an accurate diagnosis and advice.
Additional Symptoms
- New bumps or patches on the skin
- Changes in the size, shape, or color of skin growths
- Asymptomatic, discrete, soft, pale yellow, shiny bumps on the forehead or cheeks (sebaceous hyperplasia)
- Skin tags
- Moles that multiply or darken over time
- Seborrheic keratoses (may appear as brown, black, or tan spots)
Diagnostic Tests
Diagnostic Tests for Benign Neoplasms of the Integumentary System
Benign neoplasms of the integumentary system, also known as skin tumors, can be diagnosed through various diagnostic tests. Here are some common methods used to diagnose these conditions:
- Physical Examination: A thorough physical examination by a healthcare professional is often the first step in diagnosing benign skin tumors (1). This involves examining the skin lesion and taking a detailed medical history.
- Biopsy: A biopsy, where a sample of tissue is removed from the skin lesion, is sometimes required to confirm the diagnosis (3, 5, 10). There are different types of biopsies, including:
- Skin Biopsy: A skin biopsy involves removing a small sample of skin tissue for examination under a microscope (6).
- Histologic Examination: Histologic examination of a skin biopsy can help diagnose benign neoplasms and rule out cancerous conditions (5).
- Imaging Tests: Imaging tests, such as:
- Dermatoscopy: Dermatoscopy is a non-invasive diagnostic technique that uses a special microscope to examine the skin lesion (8).
- Ultrasound: Ultrasound can be used to evaluate the size and depth of the skin tumor (8).
- Other Diagnostic Techniques: Other diagnostic techniques, such as:
- Dermascopy (Epiluminescence Microscopy): Dermascopy is a non-invasive technique that uses a special microscope to examine the skin lesion (8).
- Confocal Microscopy: Confocal microscopy can be used to evaluate the skin tumor and rule out cancerous conditions (8).
It's essential to note that the choice of diagnostic test depends on the individual case, and a healthcare professional will determine the most appropriate course of action.
References:
(1) Higgins JC. (2015). Skin Cancer: A Review of the Literature. [Cited by 66]
(3) Luba MC. (2003). Diagnosis and Treatment of Benign Skin Tumors. [Cited by 147]
(5) Mar 18, 2024 - The accurate diagnosis of any skin lesions can be made by histologic examination of a skin biopsy.
(6) Sep 15, 2023 - Skin biopsies are used to diagnose skin cancer or benign skin disorders.
(8) Khandpur S. (2012). OTHER DIAGNOSTIC TECHNIQUES FOR SKIN TUMOURS. [Cited by 43]
(10) Oct 31, 2023 - Learn about tests for basal and squamous cell skin cancers.
Additional Diagnostic Tests
- Imaging Tests
- Biopsy
- Physical Examination
- Skin Biopsy
- Ultrasound
- Dermatoscopy
- Confocal Microscopy
- Histologic Examination
- Other Diagnostic Techniques
- Dermascopy (Epiluminescence Microscopy)
Treatment
Treatment Options for Benign Neoplasms of the Integumentary System
Benign neoplasms of the integumentary system, such as skin growths and tumors, can be treated with various drug therapies. Here are some treatment options:
- Photodynamic therapy (PDT): This is a non-invasive treatment that uses a light-sensitive medication and a special light to kill cancer cells. PDT has been shown to be effective in treating certain types of skin cancers, including basal cell carcinoma and squamous cell carcinoma [2].
- Chemotherapy: Chemotherapy can be used to treat skin cancers that have spread to other parts of the body. However, it is typically reserved for more advanced cases [6].
- 5-fluorouracil (5-FU): This is a type of chemotherapy drug that has been used to treat sunspots and sometimes squamous cell carcinoma in situ (Bowen's disease) [5].
- Immunotherapy: Immunotherapies, such as checkpoint inhibitors, have shown promise in treating certain types of skin cancers. However, more research is needed to fully understand their effectiveness [4].
Other Treatment Options
In addition to drug therapies, other treatment options for benign neoplasms of the integumentary system include:
- Surgery: Surgical excision is often the preferred treatment for most skin growths and tumors.
- Cryotherapy: This involves freezing the tumor with liquid nitrogen to kill it.
- Chemical peel: A chemical solution is applied to the skin to remove the top layers and treat certain types of skin cancers.
New Developments
Researchers are continually exploring new treatments for benign neoplasms of the integumentary system. For example, a study published in 2021 explored the potential of drug repurposing for treating skin cancer [10]. Other studies have investigated the use of photodynamic therapy to treat acne vulgaris and other inflammatory/infective skin diseases [3].
References
[1] Apr 13, 2023 — This page lists cancer drugs approved by the Food and Drug Administration (FDA) for skin cancer, including drugs for basal cell carcinoma, melanoma, and merkel ...
[2] by M Kim · 2015 · Cited by 144 — Photodynamic therapy (PDT) uses a photosensitizer, light energy, and molecular oxygen to cause cell damage. Cells exposed to the photosensitizer are ...
[3] by M Kim · 2015 · Cited by 145 — An increasing number of studies support the idea that PDT may be effective for treating acne vulgaris and several other inflammatory/infective skin diseases.
[4] May 15, 2023 — Chemotherapy; Photodynamic therapy; Immunotherapy; Targeted therapy; Chemical peel; Other drug therapy. New types of treatment are being tested ...
[5] A cream called 5-fluorouracil (5-FU) is a type of chemotherapy drug used to treat sunspots and sometimes squamous cell carcinoma (SCC) in situ (Bowen's disease) ...
[6] Dec 6, 2022 — Systemic chemotherapy can be used to treat skin cancers that have spread to other parts of the body. Photodynamic therapy.
[7] by MC LUBA · 2003 · Cited by 148 — Treatment includes excision, cryotherapy, curettage with or without electrodesiccation, and pharmacotherapy, and is based on the type of tumor ...
[8] Photodynamic therapy (PDT) kills cancer cells by using a combination of a light sensitising drug and a very bright light.
[9] Most skin cancer is treatable if it's caught early. Treatments include Mohs surgery, cryotherapy, chemotherapy and radiation.
[10] by H Cortés · 2021 · Cited by 16 — Drug Repurposing for Skin Cancer · Digoxin · Doxycycline · Fenofibrate · Flubendazole · Itraconazole · Leflunomide · Mebendazole · Metformin.
Recommended Medications
- Chemotherapy
- Immunotherapy
- Photodynamic therapy (PDT)
- 5-fluorouracil
- Fluorouracil
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
The differential diagnosis of integumentary system benign neoplasms involves identifying and distinguishing them from malignant tumors. According to various medical sources [1, 4, 7], the primary differential diagnoses for subcutaneous masses include:
- Spitz nevi
- Amelanotic melanoma
- Squamous or basal cell carcinoma
In addition, other common benign skin lesions that may be considered in the differential diagnosis include: * Melanocytic naevi * Seborrhoeic keratoses * Epidermoid cysts * Dermatofibromas * Pyogenic granulomas [4]
It's essential to accurately diagnose these lesions to ensure appropriate management and prevent misdiagnosis of malignant tumors. A thorough clinical examination, histopathological evaluation, and sometimes molecular testing are necessary to confirm the diagnosis [1, 7].
The differential diagnosis process involves considering various factors, such as: * Clinical presentation (e.g., location, size, shape) * Histopathological features * Molecular characteristics
A correct differential diagnosis is crucial for providing optimal patient care and preventing unnecessary treatments or delays in treatment.
References:
[1] Higgins JC. (2015). The differential diagnosis includes Spitz nevi, amelanotic melanoma, and squamous or basal cell carcinoma. Treatment options include shave excision, Mohs surgery, or wide local excision.
[4] Khandpur S. (2012). They range from benign lesions that merely cause cosmetic concern to premalignant lesions and aggressive tumours. The vast majority of skin tumours are benign.
[7] Alsaad KO. (2007). Another differential diagnosis of trichofolliculoma is pilar sheath acanthoma, which is a benign follicular tumour, usually seen in adults as small single or multiple lesions.
Additional Differential Diagnoses
- Spitz nevi
- Squamous or basal cell carcinoma
- Melanocytic naevi
- Seborrhoeic keratoses
- Epidermoid cysts
- Dermatofibromas
- Pyogenic granulomas
- amelanotic melanoma
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#created_by
- lschriml
- oboInOwl#creation_date
- 2011-07-27T01:49:44Z
- oboInOwl#id
- DOID:0060121
- IAO_0000115
- An organ system benign neoplasm located_in the integumentary system organs.
- relatedICD
- http://example.org/icd10/M27.4
- core#notation
- DOID:0060121
- rdf-schema#label
- integumentary system benign neoplasm
- rdf-schema#subClassOf
- http://purl.obolibrary.org/obo/DOID_3165
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- owl#equivalentClass
- t336522
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_1148
- owl#annotatedSource
- t336188
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It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.